Results 121 to 130 of about 469,197 (318)

Pulmonary staging in colorectal cancer: a review

, 2012
Aim: Assessment of the chest in colorectal cancer (CRC) staging is variable. The aim of this review was to look at different chest staging strategies and determine which has the greatest efficacy.
Balasingam, Adrian G, Frizelle, Frank A, Beckert, Lutz E, L. Beckert, Parnaby, Craig N, Watson, Angus, T. Eglinton, J. Fife, M. Jeffery, Bailey, Wayne, C. N. Parnaby, Eglinton, Timothy W, A. Balasingam, W. Bailey, A. J. M. Watson, F. A. Frizelle, Jeffery, Mark, Fife, James   +17 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Staging Beckett in London [PDF]

Samuel Beckett has held a long and varied relationship with London and its theatres. Although Dublin and Paris hold obvious connections with Beckett’s life, London is the city that has proved the most consistent home for his drama, the origin for many of
McFrederick, Matthew
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The IASLC lung cancer staging project : external validation of the revision of the TNM stage groupings in the eighth edition of the TNM classification of lung cancer

, 2017
: Introduction Revisions to the TNM stage classifications for lung cancer, informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external ...
Detterbeck, Frank C, Nicholson, Andrew G., Crowley, John J, Rami-Porta, Ram\uf3n, Chansky, Kari, Krasnik, Mark, Shemanski, Lynn, Valli\ue8res, Eric, Kennedy, Catherine, Rami-Porta, Ramón, Asamura, Hisao, Nicholson, Andrew G, Rusch, Valerie W, Groome, Patti, Peake, Michael, Bolejack, Vanessa, Vallières, Eric, Rusch, Valerie W., Jakobsen, Erik, Detterbeck, Frank C., Crowley, John J.   +20 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The ITMIG/IASLC thymic epithelial tumors staging project : a proposed lymph node map for thymic epithelial tumors in the forthcoming 8th edition of the TNM classification of malignant tumors

, 2014
: Although the presence of nodal disease is prognostic in thymic malignancy, the significance of the extent of nodal disease has yet to be defined. Lymph node dissection has not been routinely performed, and there is currently no node map defined for ...
Bhora, Faiz Y., van Schil, Paul, Chen, David J., Detterbeck, Frank C., et al.   +4 more
core  

Updates on World Health Organization Classification and Staging of oesophageal tumours: Implications for future clinical practice

, 2020
The Fifth edition of the World Health Organization Classification of Digestive system and American Joint Committee on Cancer (AJCC) staging manual contain substantial refinements of information for oesophageal tumours.
Lam, Alfred King-Yin
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source