Results 161 to 170 of about 879,906 (340)

Adherence to Guidelines among Italian Urologists on Imaging Preoperative Staging of Low-Risk Prostate Cancer: Results from the MIRROR (Multicenter Italian Report on Radical Prostatectomy Outcomes and Research) Study [PDF]

, 2012
Alchiede Simonato, Virginia Varca, Mauro Gacci, Paolo Gontero, Ottavio De Cobelli, Massimo Maffezzini, Roberto Salvioni, Marco Carini, Andrea DeCensi, Vincenzo Mirone, G. Carmignani   +10 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Staging and haematological abnormalities of HIV-infected persons in Mangaung in the Free State Province, South Africa

African Journal of Primary Health Care & Family Medicine, 2012
Background: The prevalence of HIV in specific areas of South Africa and its impact on haematological parameters are largely unknown.Objectives: To (1) describe the prevalence of HIV, (2) stage HIV based on CD4 counts, and (3) determine haematological ...
Andries J. Groenewald, Corinna M. Walsh, Hendrik J. van Wyk, Sanet van Zyl, Lynette J. van der Merwe   +4 more
doaj  

Enhancing multiple myeloma staging: a novel cell death risk model approach [PDF]

Zeyu Deng, Hongkai Zhu, Zhaoshun Yuan, Rong Zhang, Zhihua Wang, Heng Li, Le Yin, Xueqin Ruan, Zhao Cheng, Ruijuan Li, Hongling Peng   +10 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A retrospective analysis of delays in the diagnosis of lung cancer and associated costs

ClinicoEconomics and Outcomes Research, 2017
Thomas R Gildea,1 Stacey DaCosta Byfield,2 D Kyle Hogarth,3 David S Wilson,4 Curtis C Quinn5 1Department of Pulmonary, Allergy, and Critical Care Medicine and Transplant Center, Cleveland Clinic, Cleveland, OH, 2Health Economics and Outcomes Research ...
Gildea TR, DaCosta Byfield S, Hogarth DK, Wilson DS, Quinn CC   +4 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Staging of Prostate Cancer Using Automatic Feature Selection, Sampling and Dempster-Shafer Fusion

Cancer Informatics, 2009
A novel technique of automatically selecting the best pairs of features and sampling techniques to predict the stage of prostate cancer is proposed in this study.
Sandeep Chandana, Henry Leung, Kiril Trpkov   +2 more
doaj  

PCN6: CAN ICD-9 CODES BE USED AS A PROXY FOR DISEASE STAGING IN ECONOMIC EVALUATIONS?

, 2001
SK Thomas, SE Brooks, C. Daniel Mullins
openalex   +1 more source