Results 61 to 70 of about 7,852,620 (296)

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Influence of heterogeneous-homogeneous reactions in thermally stratified stagnation point flow of an Oldroyd-B fluid

Results in Physics, 2016
This communication explores the effects of homogeneous-heterogeneous reactions in thermally stratified mixed convection flow of an Oldroyd-B fluid. Flow situation is addressed when the diffusion coefficients of the reactant and auto catalyst are equal ...
T. Hayat, Zakir Hussain, A. Alsaedi
doaj   +1 more source

Oscillatory oblique stagnation-point flow toward a plane wall [PDF]

, 2011
Two-dimensional oscillatory oblique stagnation-point flow toward a plane wall is investigated. The problem is a eneralisation of the steady oblique stagnation-point flow examined by previous workers.
Tooke, R. M., Blyth, M. G., M. G. Blyth, Hammerton, P. W., P. W. Hammerton, R. M. Tooke   +5 more
core   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

Stagnation point radiative flow with Cattaneo-Christov theory and heat generation

Results in Engineering
Heat generation and magnetohydrodynamics for flow of Burgers liquid. Stagnation point flow towards stretched wall is considered. Radiation aspect is nonlinear. Cattaneo-Christov theory and boundary layer approximations are utilized.
Tasawar Hayat, Fatima Jaffer, Sohail A. Khan, Shaher Momani   +3 more
doaj   +1 more source

Influence of thermal stratification and slip conditions on stagnation point flow towards variable thicked Riga plate

Results in Physics, 2018
This article addresses thermally stratified stagnation point flow of viscous fluid induced by a non-linear variable thicked Riga plate. Velocity and thermal slip effects are incorporated to disclose the flow analysis.
A. Anjum, N.A. Mir, M. Farooq, M. Ijaz Khan, T. Hayat   +4 more
doaj   +1 more source

Oblique stagnation-point flow of ternary hybrid nanofluid towards a shrinking surface [PDF]

The oblique stagnation-point flow of a ternary hybrid nanofluid towards a shrinking surface is studied numerically in this paper. A similarity transformation was used to convert the governing equations into a set of ordinary differential equations, which
Rozaidi, N.L., Arifin, N.M., Hafidzuddin, M. E.H., Hafidzuddin, M.E.H., Ab Ghani, A., Rozaidi, N. L., Arifin, N. M.   +6 more
core   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

A Numerical Solution for Magneto Hydrodynamic Stagnation-point Flow towards a Stretching sheet

, 2022
Steady two-dimensional stagnation-point flow of an incompressible viscous electrically con- ducting fluid over aflat deformable sheet is investigated when the sheet is stretched in its own plane with a velocity proportional to the distancefrom the ...
Lalitkumar Shantilal Narsingani , Dr. Vishalkumar V. Patel , Dr. Jigna Panchal
core   +1 more source

Product‐Reshaped Gas‐Phase Hydrodynamics Govern CO2 Electrolysis in Gas Diffusion Electrodes

Advanced Science, EarlyView.
In gas‐fed CO2${\rm CO}_2$ electrolysers, the gas phase is part of the electrochemical response. As gaseous products form, they change gas composition and flow, which in turn affects CO2${\rm CO}_2$ delivery and CO intermediate availability. This feedback changes the reaction environment needed for multicarbon formation, becoming unavoidable as ...
Abdullah A. Alyahya, Mayra S. Tovar‐Oliva, Blessings G. Malimusi, Sebastián Murcia‐López, María Escudero‐Escribano, Timm Krüger, Ignacio Tudela   +6 more
wiley   +1 more source