Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
A STUDY OF EXPERIMENTAL NON-HEMOLYTIC STREPTOCOCCUS LESIONS IN VITALLY STAINED RABBITS [PDF]
, 1916 Russell L. Cecil
openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Technical approaches of 3D reconstruction from protein complex using the mixture of differently stained images: providing suggestive evidence for improving its resolution. [PDF]
Appl MicroscPark YH +5 more
europepmc +1 more source
Intra-Vitam Staining of Tuberculous Guinea-Pigs with Fat-Soluble Dyes: Studies on the Biochemistry and Chemo-Therapy of Tuberculosis. II [PDF]
, 1912 H. J. Corper
openalex +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
A novel optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system. [PDF]
Front Endocrinol (Lausanne)Wu J +7 more
europepmc +1 more source
THE MECHANISM OF VITAL STAINING WITH BASIC DYES [PDF]
, 1924 Morton McCutcheon, Baldwin Lucre
openalex +1 more source