Results 151 to 160 of about 478,710 (331)

Topical dual-probe staining using quantum dot-labeled antibodies for identifying tumor biomarkers in fresh specimens

, 2020
Boyu Meng, Margaret R. Folaron, Brook K. Byrd, Kimberley S. Samkoe, Rendall S. Strawbridge, Connor W. Barth, Summer L. Gibbs, Scott C. Davis   +7 more
openalex   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Application of automatic immunohistochemistry stainer in pathological diagnosis of glioma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To investigate and evaluate the Ki ⁃ 67 expression in glioma pathological diagnosis by Leica BOND⁃MAXTM automatic immunohistochemistry stainer.
Ming⁃shi GAO, Hong CHEN, Jin⁃song WU
doaj  

Transformation from hematoxylin-and-eosin staining to Ki-67 immunohistochemistry digital staining images using deep learning: experimental validation on the labeling index

Journal of Medical Imaging
Endometrial cancer (EC) is one of the most common types of cancer affecting women. While the hematoxylin-and-eosin (H&E) staining remains the standard for histological analysis, the immunohistochemistry (IHC) method provides molecular-level visualizations. Our study proposes a digital staining method to generate the hematoxylin-3,3'-diaminobenzidine (H-
Ji, Cunyuan, Oshima, Kengo, Urata, Takumi, Kimura, Fumikazu, Ishii, Keiko, Uehara, Takeshi, Suzuki, Kenji, Takeyama, Saori, Yamaguchi, Masahiro   +8 more
openaire   +2 more sources

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Simultaneous demonstration of two antigens with immunogold-silver staining and immunoenzymatic labeling

, 1993
A novel technique for independent and simultaneous labeling of two antigens expressed on individual cells (referred to as mixed labeling) is presented. The staining procedure combined three-step (streptavidin-biotin) immunogold-silver staining with three-step immunoenzymatic labeling.
Gillitzer, Reinhard, Moll, Heidrun
openaire   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Viral Identification by Scanning Electron Microscopy of Preparations Stained with Fluorescein-Labeled Antibody [PDF]

, 1974
E Springer, John L. Riggs, A. J. Hackett
openalex   +1 more source

Low-Cost, Label-Free Blue Light Cystoscopy through Digital Staining of White Light Cystoscopy Videos

Communications Medicine
AbstractBladder cancer is 10thmost common malignancy and carries the highest treatment cost among all cancers. The high cost of bladder cancer treatment stems from its high recurrence rate, which necessitates frequent surveillance. White light cystoscopy (WLC), the standard of care surveillance tool to examine the bladder for lesions, has limited ...
Shuang Chang, Greyson A. Wintergerst, Camella Carlson, Haoli Yin, Kristen R. Scarpato, Amy N. Luckenbaugh, Sam S. Chang, Soheil Kolouri, Audrey K. Bowden   +8 more
openaire   +3 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source