Results 61 to 70 of about 10,457 (255)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Sunflowers are being grown in the Northeast for their potential to add value to a diversified operation as fuel, feed, fertilizer, and an important rotational crop. The major sunflower production areas are in the northern Great Plains, so seed production
Burke, Conner +4 more
core +1 more source
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Increased optimal plant density is necessary in ensuring future food security by increasing crop productivity. However, maintaining relatively high plant density has to overcome two challenges i.e. kernel abortion and stalk lodging.
Alam Sher +4 more
doaj
Stalk strength is one of the most important traits in maize, which affects stalk lodging resistance and, consequently, maize harvestable yield. Rind penetrometer resistance (RPR) as an effective and reliable measurement for evaluating maize stalk ...
Xinwei Hou +10 more
doaj +1 more source
Changes of Weight and in-Kernel Content Values of Maize Hybrids (Occitan, Colomba, DK-471) as a Result of Damaging dy European Corn Borer. Kukorica hibridek (Occitan, Colomba, DK-471) súly- és beltartalmi érték változása a kukoricamoly (Ostrinia nubilalis Hbn.) károsítása következtében. [PDF]
ÖSSZEFOGLALÁS Vizsgálatunkat 2001-ben két tábla három különböző hibriddel elvetett állományában vizsgáltuk véletlenszerű mintaterek kijelölésével. Első felmérésünket egy 120 ha-os COLOMBA és OCCITAN, míg a második vizsgálatunkat egy 50 ha-os DK-471-es
Keszthelyi, Sándor, Takács, András
core
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source

