Results 191 to 200 of about 24,787 (347)

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

open access: yesBrain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong   +8 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos   +16 more
wiley   +1 more source

Action Design Research for Actionable Knowledge Production: A Metareflexive Methodology for Digital Transformation and Innovation Studies

open access: yesCreativity and Innovation Management, EarlyView.
ABSTRACT The sociotechnical complexities and hidden dynamics shaping the evolution of digital transformation (DT) and innovation initiatives frequently elude traditional research approaches reliant on retrospective analysis, static and detached observation.
Siobhán Diglas, Kisito F. Nzembayie
wiley   +1 more source

Prospective association of device‐based physical activity and sedentary time during childhood with mental health outcomes during adolescence

open access: yesChild and Adolescent Mental Health, EarlyView.
Background The present study aimed to analyze associations between device‐measured physical activity and sedentary time during childhood with mental health‐related outcomes throughout adolescence. Methods Data from the Millennium Cohort Study were used.
André O. Werneck   +11 more
wiley   +1 more source

A global effort toward standards for data sharing in biomedical imaging : Developing Consensus and Infrastructure for Global Data Interoperability. [PDF]

open access: yesEMBO Rep
Winter SL   +8 more
europepmc   +1 more source

The technical and practical implementation of fundus photography in equids

open access: yesEquine Veterinary Education, EarlyView.
Summary Background Fundus photography is an important diagnostic tool in human and veterinary medicine. Advances in research are increasing its accessibility in human medicine. However, there is a lack of studies on modern fundus photography in animals, particularly in horses. Objectives To assess the use of a portable fundus camera developed for human
I. Vierling, B. Wollanke, V. Franzen
wiley   +1 more source

Home - About - Disclaimer - Privacy