Results 81 to 90 of about 38,124 (276)

Deadly dark matter cusps vs faint and extended star clusters: Eridanus II and Andromeda XXV

open access: yes, 2017
The recent detection of two faint and extended star clusters in the central regions of two Local Group dwarf galaxies, Eridanus II and Andromeda XXV, raises the question of whether clusters with such low densities can survive the tidal field of cold dark
Amorisco, Nicola C.
core   +1 more source

Passivation‐Induced Species Dynamics and Microstructural Evolution in Solid‐State Lithium–Sulfur Cathodes

open access: yesAdvanced Science, EarlyView.
The formation of insulating Li2S during discharge in solid‐state lithium–sulfur batteries passivate reaction sites and limits sulfur utilization. In this work, a microstructure‐resolved modeling framework coupling transport and reaction kinetics is developed to predict charge–discharge behavior and reveal particle‐scale species evolution and incomplete
Arpan K. Sharma   +4 more
wiley   +1 more source

Explainable machine learning prediction of internet addiction among Chinese primary and middle school children and adolescents: a longitudinal study based on positive youth development data (2019–2022)

open access: yesFrontiers in Public Health
BackgroundInternet Addiction (IA) has emerged as a critical concern, especially among school age children and adolescents, potentially stalling their physical and mental development.
Jiahe Liu   +11 more
doaj   +1 more source

Actin filaments growing against a barrier with fluctuating shape

open access: yes, 2016
We study force generation by a set of parallel actin filaments growing against a non-rigid obstacle, in presence of an external load. The filaments polymerize by either moving the whole obstacle, with a large energy cost, or by causing local distortion ...
Chatterjee, Sakuntala, Sadhu, Raj Kumar
core   +1 more source

Hysteresis behaviors of compressor rotating stall with cusp catastrophic model

open access: yesChinese Journal of Aeronautics, 2018
Abstract Rotating stall is a complex nonlinear dynamic phenomenon which is always characterized by catastrophe and hysteresis in high aerodynamic-loading compressor. Exploring the key contributing factors and characteristic rules of hysteresis is very important for compressor design and flow instability control. In this paper, a novel model method is
Zhiping LI   +4 more
openaire   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

open access: yesAdvanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo   +8 more
wiley   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji   +10 more
wiley   +1 more source

Numerical Simulation of Unsteady Flow Past a Rotating Wells Turbine with Modified Blades

open access: yes한국해양공학회지
Wells turbines used in wave power generation have the advantage of being usable in reciprocating flow, but they also face many unsolved problems, such as self-starting performance, low efficiency, and noise.
Eru Kurihara   +3 more
doaj   +1 more source

Mutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase

open access: yes, 2015
The dnaQ gene of Escherichia coli encodes the Ɛ subunit of DNA polymerase III, which provides the 3\u27 - 5\u27 exonuclease proofreading activity of the replicative polymerase.
Kreuzer, Kenneth N., Whatley, Zakiya
core   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

open access: yesAdvanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang   +11 more
wiley   +1 more source

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