Results 131 to 140 of about 2,953,852 (350)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Decoupling of beams previously coupled by effective stand-alone solenoid fringe fields
, 2014 Beams passing through a solenoid fringe field experience x-y coupling and change of their eigen-emittances. As reported previously (C.~Xiao et al., Phys. Rev. ST Accel. Beams 044201, {\bf 16} 2013) constant settings of a subsequent decoupling section can
Groening, Lars
core
An In-Depth Examination of Formularies and Other Features of Medicare Drug Plans [PDF]
, 2006 Provides a detailed assessment of the formularies, drug costs, and utilization management tools offered by the fourteen nationwide organizations that account for most of the stand-alone prescription drug ...
Elizabeth Hargrave +3 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A New Stand-Alone MAC Construct Called SMAC
IACR Transactions on Symmetric CryptologyIn this paper, we present a new efficient stand-alone MAC construct named SMAC, based on processing using the Finite State Machine (FSM) part of the stream cipher family SNOW, which in turn uses the AES round function.
Dachao Wang +3 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Control aspects of the Schuchuli Village stand-alone photovoltaic power system [PDF]
A photovoltaic power system in an Arizona Indian village was installed. The control subsystem of this photovoltaic power system was analyzed. The four major functions of the control subsystem are: (1) voltage regulation; (2) load management; (3) water ...
Culler, J. E. +2 more
core +1 more source