Results 101 to 110 of about 306,417 (304)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Stand Age Influence on Potential Wildfire Ignition and Spread in the Boreal Forest of Northeastern Canada [PDF]

, 2018
Although it has long been assumed that wildfire occurrence is independent of stand age in the North American boreal forest, recent studies indicate that young forestsmay influence burn rates by limiting the ignition and spread of fires for several years.
Erni, Sandy, Dominique Arseneault, Arseneault, Dominique, Marc-André Parisien, Parisien, Marc-André, Sandy Erni   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modeling age-related stand respiration changes in forest stands under the self-thinning law [PDF]

, 2017
There are three different age-related changes in stand respiration (woody + foliage respiration) in an even-aged pure forest stand after canopy closure: (A) monotonous increase (Kira and Shidei, 1967; Odum, 1969), (B) constancy (Oohata and Shidei, 1974 ...
Ogawa, Kazuharu, Kazuharu Ogawa
core   +1 more source

Plant Diversity and Microbial Community Drive Ecosystem Multifunctionality in Castanopsis hystrix Plantations

Plants
Monoculture plantation systems face increasing challenges in sustaining ecosystem multifunctionality (EMF) under intensive management and climate change, with long-term functional trajectories remaining poorly understood.
Han Sheng, Babar Shahzad, Fengling Long, Fasih Ullah Haider, Xu Li, Lihua Xian, Cheng Huang, Yuhua Ma, Hui Li   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The criteria of maturity age of a stand to regenerate

, 2003
Stand characteristics were analysed for the occurrence of regrowth with a species matching the dominant species of a stand. The analysis covered: stand age, stocking, degree of shelter (the sum of stocking plus the percentage of the shrub layer cover ...
Głaz, J.
core