Results 111 to 120 of about 11,437,124 (248)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Using codispersion analysis to quantify temporal changes in the spatial pattern of forest stand structure [PDF]

, 2016
Forest development involves a complex set of ecological processes, such as dispersal and competition for light, which can generate a range of spatial patterns in forest structure that change through time.
Case, B, Plotkin, A, Ellison, Aaron, Case, BS, Buckley, H., Barker Plotkin, A, Ellison, AM, Buckley, HL   +7 more
core   +1 more source

Multi-objective optimization of forest structure for broadleaf mixed forest under different CMIP5 scenarios

Ecological Indicators
Climate change is an important global research topic and one of the most pressing issues facing the world today. It significantly impacts forest distribution, species composition, stand structure, growth, and other functions, therefore, it is crucial to ...
Qi Sheng, Lingbo Dong, Zhaogang Liu
doaj   +1 more source

Simulation of variable structure stands for use of spatial "Tree" models

, 2007
Pour étudier les peuplements forestiers mélangés ou irréguliers, les dendrométriciens construisent des modèles de l’évolution individuelle de chaque arbre, en fonction de ses caractéristiques et de son environnement local. Ces modèles “arbre” dépendant des distances peuvent être difficiles à utiliser, car il faut spécifier au simulateur les ...
Goreaud, François, Allain, Régis, Courbaud, Benoît, Ngo Bieng, Marie-Ange, Pérot, Thomas, Piroche, Jean-Noël   +5 more
openaire   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Influence of Tree Species Composition and Community Structure on Carbon Density in a Subtropical Forest.

PLoS ONE, 2015
We assessed the impact of species composition and stand structure on the spatial variation of forest carbon density using data collected from a 4-ha plot in a subtropical forest in southern China.
Yanqiu Hu, Zhiyao Su, Wenbin Li, Jingpeng Li, Xiandong Ke   +4 more
doaj   +1 more source

Optimizing neighborhood-based stand spatial structure: Four cases of boreal forests

Forest Ecology and Management, 2022
Ling-Bo Dong, P. Bettinger, Zhao-Gang Liu   +2 more
semanticscholar   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source