Results 101 to 110 of about 10,646,513 (253)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Risk stratification and long-term monitoring in pediatric thyroid cancer: predictive markers for disease persistence

European Thyroid Journal
Background: Initial risk stratification and dynamic risk stratification are crucial in managing pediatric differentiated thyroid carcinoma (DTC), aiming to guide treatment and long-term follow-up.
Mariana Mazeu Barbosa de Oliveira, Laura Sterian Ward, Adriano Namo Cury, Nilza Maria Scalissi, Marilia Martins Silveira Marone, Carlos Alberto Longui, Cristiane Kochi, Osmar Monte, Carolina Ferraz, Rosália Padovani   +9 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Effects of Dissolved Organic Carbon Leaching and Soil Carbon Fractions Under Intercropping Dactylis glomerata L.–Medicago sativa L. in Response to Extreme Rainfall

Agronomy
Climate change aggravates the frequency of extreme rainfall events, resulting in carbon (C) loss. For the special climate of the highlands, cultivating the land underneath orchards increases C reservation.
Cui Xu, Peng Zhang, Lu Chen, Wenzhi Wang, Xukun Yang, Zhenhuan Liu, Yanhua Mi   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Iterative Retrieval‑Augmented Generation Method for Aviation Standards Based on Large Language Models

Nanjing Hangkong Hangtian Daxue Xuebao
Aviation standards are characterized by complex data structures， rigorous semantics， and frequent cross‑document references， which pose significant challenges for achieving efficient and accurate knowledge acquisition and question‑answering applications.
QIN Xiaorui, HE Liu, AN Ran, ZENG Jianghui, LIU Shuyan, WANG Shaofeng, TIAN Yu   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The potential of low temperature extraction method for analysis of polycyclic aromatic hydrocarbons in refined olive and refined pomace olive oils by HPLC/FLD

Nutrition and Food Sciences Research, 2015
Background and Objectives: A method was developed and validated for determining 15 polycyclic aromatic hydrocarbons (PAHs) in refined olive and refined pomace olive oils using high performance liquid chromatography coupled with a fluorescence detector ...
Zohreh Taghvaee, Zahra Piravivanak, Keramatollah Rezaee, Mohammad Faraji, Sara Nanvazadeh   +4 more
doaj  

Standards and standard-compliance [PDF]

Standards in Genomic Sciences, 2009
openaire   +2 more sources