Results 91 to 100 of about 1,521,543 (298)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Rules of Origin under the Australia–New Zealand CER Trade Agreement [PDF]

Rules of origin arrangements under the Australia–New Zealand Closer Economic Relations Trade Agreement (CER) were referred to the Commission for examination and report by May 2004.
Productivity Commission
core  

The Urgency of Banks in Implementing the Precautionary Principle as Consumer Protection in the Standard Clauses of Credit Agreements

Media Iuris
The importance of the bank in applying the precautionary principle contributes to ensuring a sound banking system and protecting the country’s economy. In lending, the precautionary principle was manifested in a standard agreement between the bank as the
Farid Irfan Sidik, Sri Astutik, Ernu Widodo, Noenik Soekorini, Izzah Khalif Raihan Abidin   +4 more
doaj   +1 more source

Concordância dos ortodontistas no diagnóstico do padrão facial Agreement among orthodontists regarding facial pattern diagnosis

Dental Press Journal of Orthodontics, 2011
OBJETIVO: avaliar a concordância de ortodontistas treinados no diagnóstico do Padrão Facial, por meio da avaliação morfológica da face. MÉTODOS: foram utilizadas fotografias faciais de frente, perfil e sorriso de 105 indivíduos selecionados ...
Sílvia Augusta Braga Reis, Jorge Abrão, Cristiane Aparecida Assis Claro, Renata Ferraz Fornazari, Leopoldino Capelozza Filho   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Attribute-based authenticated key agreement protocol supporting revocation

Tongxin xuebao, 2014
Revocation is a crucial issue for the practical use of attribute-based authenticated key agreement (ABAKA) protocols. A new ABAKA protocol supporting revocation was proposed.
Qiang LI, Deng-guo FENG, Li-wu ZHANG
doaj   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Agreement between Ultra-Short-Term and Standard Heart Rate Variability Analysis in Resting and Post-Exercise Conditions

Life
Background: Short-term (5 min) heart rate variability (HRV) analysis is widely used in assessing autonomic nervous system activity during exercise. While shortening the HRV measurement duration can help improve its application efficiency, its accuracy ...
Kai Jin, Zhenxiang Guo, Zining Qiao, Meng Liu, Yi Yang, Changnan Xu   +5 more
doaj   +1 more source