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The first modern pedagogically oriented reference to the grammar of standard Basque (Euskara Batua), in two volumes: Part 1 presents detailed grammar lessons, Part 2 glosses and supplementary materials.Intro -- Contents -- Map of the Basque Country ...
Rijk, Rudolf P. G. de. +2 more
core

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source

Validation of a Low-Cost Handheld Dynamometer Against a Standard Device for Handgrip Strength Assessment in Stable Outpatients with Cirrhosis. [PDF]

J Frailty Sarcopenia Falls
Chakraborty S +7 more
europepmc +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source

Fully automated artificial intelligence-based echocardiographic analysis substantially reduces workflow time while preserving measurement accuracy: a pilot study. [PDF]

J Cardiovasc Imaging
Sun J +8 more
europepmc +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source

Accuracy and Agreement of a 45 mg Versus a 75 mg <sup>13</sup>C-Urea Breath Test for the Diagnosis of <i>Helicobacter pylori</i> Infection in Adults: A Randomized Crossover Trial. [PDF]

Diagnostics (Basel)
Huang J, Xie Y, Huang J, Lu B, Chen Y.
europepmc +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source

Validation of an automated AI-based micro-CT organ segmentation workflow against expert annotations and its impact on fluorescence quantification. [PDF]

Eur Radiol Exp
Rama E +8 more
europepmc +1 more source

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standard arabic
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