Results 201 to 210 of about 309,227 (254)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Computing standard deviations

Communications of the ACM, 1979
Four algorithms for the numerical computation of the standard deviation of (unweighted) sampled data are analyzed. Two of the algorithms are well-known in the statistical and computational literature; the other two are new algorithms specifically intended for automatic computation.
Chan, Tony F., Lewis, J.G.
openaire   +1 more source

Standard deviation [PDF]

open access: yes, 2018
This encyclopedia entry briefly defines standard ...
Fritz, Catherine O, Morris, Peter E
openaire   +2 more sources

Standard deviation or the standard error of the mean

BMJ, 2015
The effects of a diet with a low glycaemic index during pregnancy on maternal and neonatal morbidity for women at risk of fetal macrosomia (large for gestational age infants) were investigated. A randomised controlled trial was performed. The intervention consisted of a low glycaemic index diet from early pregnancy. The control treatment was no dietary
openaire   +2 more sources

The Standard Deviation

1978
Sometimes two or more distributions will have the same, or essentially the same, means but still be quite different. Mexico City lies in the torrid zone, but because of its altitude of 7,556 feet, in recent years it has had an average temperature of 59.9 °F. The corresponding figure for Nashville, Tennessee, is 60.0 °F.
Albert K. Kurtz, Samuel T. Mayo
openaire   +1 more source

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