Results 131 to 140 of about 1,161,301 (313)
Single-drug pharmacodynamic function parameter estimates and standard errors.
, 2012 Single-drug pharmacodynamic function parameter estimates and standard errors.
Bruce R. Levin (105441) +1 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Evaluating Uncertainty in Dengue Seroprevalence in the Absence of a Gold Standard Diagnostic Test
McGill Journal of Medicine, 2020 Background: Shortly after the introduction of the first licensed vaccine against dengue fever (Dengvaxia), a serious outcome was attributed to the vaccine: vaccinated individuals without a previous dengue infection were at increased risk of developing ...
Tess Baker, David B. Wolfson
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Significance of life table estimates for small populations: Simulation-based study of estimation errors [PDF]
We study bias, standard errors, and distributions of characteristics of life tables for small populations. Theoretical considerations and simulations show that statistical efficiency of different methods is, above all, affected by the population size ...
Dalkhat Ediev, Sergei Scherbov
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
مجله اپیدمیولوژی ایران, 2019 Background and Objectives: Analysis of ordinal data outcomes could lead to bias estimates and large variance in sparse one. The objective of this study is to compare parameter estimates of an ordinal regression model under maximum likelihood and Bayesian
M Chehrazi +4 more
doaj
Carbon Abatement Costs: Why the Wide Range of Estimates? [PDF]
Estimates of marginal abatement costs for reducing carbon emissions derived from major economic-energy models vary widely. Controlling for policy regimes, we use meta-analysis to examine the importance of structural modeling choices in explaining ...
Fischer, Carolyn, Morgenstern, Richard
core
Mapping data: two point linkage estimates and standard errors.
, 2013 Composite two point linkage estimates and standard errors for each linkage group in the Culex pipiens genetic ...
Mori, Akio +7 more
core +1 more source