From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
On <i>p</i>-adic <i>L</i>-functions for symplectic representations of GL ( N ) over number fields. [PDF]
Williams C.
europepmc +1 more source
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
High-salt and high-sucrose diets may not reliably induce hypertension or diabetes in rat models. [PDF]
Chong L +8 more
europepmc +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
YoLeTooth: A Unified Framework for Joint Tooth Segmentation and Periapical Lesion Detection in Panoramic Radiographs. [PDF]
Scarano G +3 more
europepmc +1 more source
Response to Letter to the Editor Regarding "A bibliometric analysis of investigative genetic genealogy in academic literature: Trends, networks, and emerging themes". [PDF]
Pellegrino A, Stasi A.
europepmc +2 more sources
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Fault diagnosis of aero-engines using transfer dispersion entropy and dispersion patterns. [PDF]
Zhang H, Zhang Y, Liu J, Dong K.
europepmc +1 more source

