Results 161 to 170 of about 955,318 (314)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Japan [cartographic material] /
, 1964 Ed. 2-AMS. Map of Japan showing international and administrative boundaries, transportation, water features and populated places. Relief shown by hypsometric tints, contours and spot heights.; Standard map series designation: Series 5204.; Includes index
United States. Army Map Service.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The dilatation of some standard mappings [PDF]
Pacific Journal of Mathematics, 1967 openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Ecuador 1:50,000 [cartographic material] /
, 1965 Ed. 1-AMS. Relief shown by contours and soundings.; Standard map series designation: Series J722.; Includes grid data, magnetic declination, glossary, and adjoining sheets.; Each sheet is named and numbered individually.; Map series of Ecuador showing ...
United States. Army Map Service.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Asia 1:1,500,000 [cartographic material].
, 1942 Various editions. Topographic map series of Asia showing international and district boundaries, transportation, water features, vegetation, religious, industrial, historical and public buildings, populated places and density.
United States. Army Map Service.
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Japan 1:250,000 [cartographic material] /
, 1954 Topographic map series of Japan and Kurile Islands showing international and administrative boundaries, transportation, ground and water features, vegetation and populated places.
United States. Army Map Service.
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