Results 141 to 150 of about 11,016,214 (297)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment: DUNE Collaboration. [PDF]

open access: yesEur Phys J C Part Fields, 2021
Abi B   +977 more
europepmc   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Solution of the dark matter riddle within standard model physics: from black holes, galaxies and clusters to cosmology

open access: yesFrontiers in Astronomy and Space Sciences
It is postulated that the energy density of the (quantum) vacuum acts firstly as dark energy and secondly as a part of dark matter. Assisted by electric fields arising from a small charge mismatch in the cosmic plasma, it can condense on mass ...
Theodorus Maria Nieuwenhuizen
doaj   +1 more source

Evaluation of a Multidisciplinary Integrated Treatment Approach Versus Standard Model of Care for Functional Gastrointestinal Disorders (FGIDS): A Matched Cohort Study. [PDF]

open access: yesDig Dis Sci, 2022
Bray NA   +15 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Digital pathology for the routine diagnosis of renal diseases: a standard model. [PDF]

open access: yesJ Nephrol, 2021
L'Imperio V   +5 more
europepmc   +1 more source

The Standard Model as a noncommutative geometry: the low-energy regime [PDF]

open access: green, 1998
Carmelo P. Martín   +2 more
openalex   +1 more source

AN INVESTIGATION TURBULENCE MODEL OF STANDARD k- TO GET OPTIMUM PARAMETERS OF TURBULENCE CONSTANTS (cµ, c1, AND c2) OF COMPRESSIBLE FLUID DYNAMICS IN A CONFINED JET

open access: bronze, 2021
Ahmad Indra Siswantara   +4 more
openalex   +2 more sources

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