Results 171 to 180 of about 4,031,297 (266)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A standard model of Alzheimer's disease? [PDF]

open access: yesPrion, 2018
Walker LC, Lynn DG, Chernoff YO.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Predictability, an Orrery, and a Speciation Machine: Quest for a Standard Model of Speciation. [PDF]

open access: yesCold Spring Harb Perspect Biol
Roesti M   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

FURTHER STUDY OF THE HIGGS BOSON PROPERTIES, SUCH AS ITS COUPLINGS AND POTENTIAL DEVIATIONS FROM THE STANDARD MODEL PREDICTIONS

open access: yesWorldwide Journal of Physics
The study of the Higgs boson, a fundamental particle of the Standard Model of particle physics, continues to be a focal point of scientific inquiry. This abstract highlights ongoing research aimed at unraveling the Higgs boson's properties, particularly ...
Iqbal Ahmed   +2 more
doaj  

Search for physics beyond the standard model in events with jets and two same-sign or at least three charged leptons in proton-proton collisions at s = 13 TeV. [PDF]

open access: yesEur Phys J C Part Fields, 2020
Sirunyan AM   +2293 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

PRyMordial: the first three minutes, within and beyond the standard model. [PDF]

open access: yesEur Phys J C Part Fields
Burns AK, Tait TMP, Valli M.
europepmc   +1 more source

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