Results 171 to 180 of about 11,143,812 (289)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sub-part-per-trillion test of the Standard Model with atomic hydrogen. [PDF]

Nature
Maisenbacher L, Wirthl V, Matveev A, Grinin A, Pohl R, Hänsch TW, Udem T.   +6 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Implicit neural representations for accurate estimation of the Standard Model of white matter. [PDF]

Commun Biol
Hendriks T, Arends G, Versteeg E, Vilanova A, Chamberland M, Tax CMW.   +5 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Building toward a standard model for perinatal mental healthcare. [PDF]

Front Psychiatry
Sheldrick RC, Hansen MD, Cirino NH, Kimmel M, King C, Logan D, Menke R, Tabb K.   +7 more
europepmc   +1 more source

Creation of a Standard Model for Tube Feeding at Neonatal Intensive Care Unit Discharge. [PDF]

JPEN J Parenter Enteral Nutr, 2020
White BR, Ermarth A, Thomas D, Arguinchona O, Presson AP, Ling CY.   +5 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Comparing the motion of dark matter and standard model particles on cosmological scales. [PDF]

Nat Commun
Grimm N, Bonvin C, Tutusaus I.
europepmc   +1 more source

Effects of Pulsed Radiofrequency on a Standard Model of Muscle Injury in Rats. [PDF]

Anesth Pain Med, 2020
Brasil LJ, Marroni N, Schemitt E, Colares J.   +3 more
europepmc   +1 more source