Results 81 to 90 of about 108,730 (272)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
IET Networks, 2016 The standardisation of the 10 GB‐capable passive optical network (XG‐PON) system is accompanied by a rigorous set of recommendations. Power reduction in XG‐PONs is considered a quite important topic by the telecommunication standardisation sector (ITU‐T),
Panagiotis Sarigiannidis +3 more
doaj +1 more source
Digital Clients: An Example of People Production in Social Work
Social Inclusion, 2019 Digital work has become part of social workers’ daily routines in countries where digitalisation is on the agenda. As a consequence, documentation practices are expanding—on paper as well as digitally—and include reporting detailed statistics about ...
Elizabeth Martinell Barfoed
doaj +1 more source
Standardisation is essential: Standardisation is essential [PDF]
BMJ, 1994 W D, Alexander, K R, Paterson
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Clinical requirements for extracellular vesicle assays
Journal of Extracellular Vesicles, 2019 The scientific and clinical interest in extracellular vesicles (EV) has grown exponentially during the past 15 years. As most research indicates that EVs can be utilised in diagnostics, prognostics and therapeutics, we may be on the brink of establishing
Lisa Ayers +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Standardisation - Enabler for nanotechnology innovation [PDF]
, 2019 Nanotechnology is an amazing field of innovation – both in terms of the materials used and of products made. However, the technology carries many risks and uncertainties: it may pose harm to people, nature, and the environment.
Schwarz-Plaschg, C. +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source