Results 81 to 90 of about 173,214 (212)

From Haugen’s codification to Thomas’s purism: assessing the role of description and prescription, prescriptivism and purism in linguistic standardisation

Language Policy, 2019
Haugen’s model (in  Sociolinguistics , Penguin, Harmondsworth, pp 97–111, 1972 [1966]) of standardisation has been widely adopted in general histories of particular languages, not least because of its clarity and simplicity.
W. Ayres-Bennett
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Development and Validation of an Analytical Procedure for the Determination of Caffeic Acid in Nonea rossica Herb by HPLC

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. According to the literature, alcoholic extracts of Nonea rossica Steven have anticoagulant, antimicrobial, and antifungal properties, which may be due to the presence of caffeic acid and its derivatives in the plant.
V. V. Velichko, A. V. Lastovka, M. E. Kartashova, A. A. Gaiduk, D. S. Kruglov   +4 more
doaj   +1 more source

Hepatoprotective effect of Lobelia alsinoides Lam. in Wistar rats

Journal of Ayurveda and Integrative Medicine, 2020
Background: Traditional healing practitioners of South India use fine paste (an Ayurvedic dosage form known as ‘kalka’) of Lobelia alsinoides Lam., an ethno medicinal plant for curing hepatic diseases.
Raj R.V. Binitha, M.A. Shajahan, Jaseer Muhamed, Thapasimuthu V. Anilkumar, S. Premlal, V.C. Indulekha   +5 more
doaj   +1 more source

The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial

The Lancet, 2008
Summary Background The international standard radiotherapy schedule for early breast cancer delivers 50 Gy in 25 fractions of 2·0 Gy over 5 weeks, but there is a long history of non-standard regimens delivering a lower total dose using fewer, larger ...
R. Agrawal, E. Aird, J. Barrett, P. Barrett-Lee, S. Bentzen, J. Bliss, Julia Brown, J. Dewar, H. Dobbs, J. Haviland, Peter Hoskin, P. Hopwood, P. Lawton, B. Magee, J. Mills, D. Morgan, J. Owen, S. Simmons, G. Sumo, M. Sydenham, K. Venables, J. Yarnold   +21 more
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Quantitative Determination of Major Active Components in Polymyxin B Medicinal Products by NMR Spectroscopy

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Polymyxin B is a natural multicomponent antibiotic used in its sulfate form for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. Pharmacopoeial standards for polymyxin B medicinal products include limits for
N. E. Kuz’mina, S. V. Moiseev, I. Yu. Yakupov, S. I. Kuleshova   +3 more
doaj   +1 more source

Multi-mode standardisation: A critical review and a research agenda

, 2017
Standardisation is key to shaping new technologies and supporting major ongoing trends, such as the increased importance of platforms, developing ‘smart’ technologies and innovating large-scale complex systems. Standardisation plays a key role in shaping
P. M. Wiegmann, H. D. Vries, K. Blind
semanticscholar   +1 more source