Results 61 to 70 of about 26,269 (254)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The Use Of Standardized Indicators (SPI And SPEI) In Predicting Droughts Over The Republic Of Moldova Territory

Present Environment and Sustainable Development, 2015
The drought events frequent manifestation over the Republic of Moldova territory, in the context of climate change requires a scientific monitoring adjusted to international researchers. In recent years, internationally, the estimation of this phenomenon
Nedealcov M., Răileanu V., Sîrbu R., Cojocari R.   +3 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Neural Hierarchical Interpolation for Standardized Precipitation Index Forecasting

Atmosphere
In the context of climate change, studying changes in rainfall patterns is a crucial area of research, remarkably so in arid and semi-arid regions due to the susceptibility of human activities to extreme events such as droughts.
Rafael Magallanes-Quintanar, Carlos Eric Galván-Tejada, Jorge Isaac Galván-Tejada, Hamurabi Gamboa-Rosales, Santiago de Jesús Méndez-Gallegos, Antonio García-Domínguez   +5 more
doaj   +1 more source

Prediction of Local Alterations in the Relative Amounts of Temperature and Precipitation Caused by Climate Change in Near and Far Future, and Drought Investigation Using SPI and SPEI Indices in Qazvin Plain, Iran

علوم آب و خاک, 2021
The upcoming climate change has become a serious concern for the human society. These changes, caused and aggravated by the industrial activities of the international community and the increase in the concentration of greenhouse gases in the atmosphere ...
S. Banihashemi, S. S. Eslamian, B. Nazari   +2 more
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A High Resolution Dataset of Drought Indices for Spain

Data, 2017
Drought indices are essential metrics for quantifying drought severity and identifying possible changes in the frequency and duration of drought hazards. In this study, we developed a new high spatial resolution dataset of drought indices covering all of
Sergio M. Vicente-Serrano, Miquel Tomas-Burguera, Santiago Beguería, Fergus Reig, Borja Latorre, Marina Peña-Gallardo, M. Yolanda Luna, Ana Morata, José C. González-Hidalgo   +8 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Categorical Forecast of Precipitation Anomaly Using the Standardized Precipitation Index SPI [PDF]

Water, 2016
In the paper, the verification of forecasts of precipitation conditions measured by the standardized precipitation index (SPI) is presented. For the verification of categorical forecasts, a contingency table was used. Standard verification measures were used for the SPI value forecast.
openaire   +1 more source