Results 51 to 60 of about 26,269 (254)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and Temporal Analysis of Drought Characteristics in Parambikulam-Aliyar Sub-basin, Tamil Nadu

International Journal of Bio-Resource and Stress Management, 2023
Drought assessment in a basin provides useful information for sustainable water resource planning and management. The impacts of drought assessment and projection for the Parambikulam–Aliyar sub-basin was carried out with the aid of Regional Climate ...
R. Vinoth kumar, S. Arunvenkatesh, S. Janapriya, M. Rajasekar, I. Muthuchamy   +4 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatio-Temporal Analysis of Drought Vulnerability using the Standardized Precipitation Index (Case study: Semnan Province, Iran) [PDF]

Desert, 2009
This study was conducted to identify drought event and its emerging regions in Markazi desert, Iran with focus onSemnan province in a 30 years statistical period. In this research, 61 stations having adequate data selected and usedafter extracting annual
M. Karimpour Reyhan, Y. Esmaeilpour, A. Malekian, N. Mashhadi, N. Kamali   +4 more
doaj   +1 more source

Drought Assessment Using Standard Precipitation Index [PDF]

International Journal of Trend in Scientific Research and Development, 2018
Drought is one of the extreme climatic events among the most relevant natural disasters. This paper presents drought assessment using Standardized Precipitation Index SPI to overview the respective drought hot spots. Monthly rainfall data during the previous 36 years 1982 - 2017 are applied to generate Standardized Precipitation Index SPI with 3 month ...
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Standardized Precipitation Index Forecasting Comparison Using Transformer Models

Forecasting
Accurate long-horizon drought forecasting is essential for water resource management and early warning systems in semi-arid regions. This study evaluates five state-of-the-art Transformer architectures—Vanilla Transformer, Informer, Autoformer, Temporal ...
Rafael Magallanes-Quintanar, Carlos Eric Galván-Tejada, Jorge Isaac Galván-Tejada, Santiago de Jesús Méndez-Gallegos, Antonio García-Domínguez   +4 more
doaj   +1 more source

Predicting Standardized Streamflow index for hydrological drought using machine learning models

Engineering Applications of Computational Fluid Mechanics, 2020
Hydrological droughts are characterized based on their duration, severity, and magnitude. Among the most critical factors, precipitation, evapotranspiration, and runoff  are essential in modeling the droughts. In this study, three indices of drought, i.e.
Shahabbodin Shamshirband, Sajjad Hashemi, Hana Salimi, Saeed Samadianfard, Esmaeil Asadi, Sadra Shadkani, Katayoun Kargar, Amir Mosavi, Narjes Nabipour, Kwok-Wing Chau   +9 more
doaj   +1 more source