Results 131 to 140 of about 666,866 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Standardized testing in Turkey: EFL teachers’ perceptions and experiences on Cambridge YLE exams : Standardized testing in Turkey

, 2023
This study evaluated EFL Teachers’ Perceptions and Experiences on Cambridge YLE Exams. In this context, the purpose of the research is to determine the perceptions of Turkish EFL teachers towards the general implementation process of Cambridge YLE Exams,
Höl, Devrim
core  

Educators Cheating on Tests Is Nothing New; Doing Something About It Would Be

Nonpartisan Education Review, 2011
no ...
Richard P. Phelps
doaj  

Considering the Impact of Standardized Testing on Workforce Diversity

Impacting Education
Today, we revisit our initial stance of eliminating standardized test scores from the college admissions process to improve equity and student diversity.
Lyndon Huling, Cynthia Sommer, Ira Young
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Economics of Standardized Testing (slide show)

Nonpartisan Education Review, 2006
no ...
Richard P. Phelps
doaj  

Standardized Testing, Use of Assessment Data, and Low Reading Performance of Immigrant and Non-immigrant Students in OECD Countries. [PDF]

Front Sociol, 2020
Teltemann J, Schunck R.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

High-stakes Standardized Testing in Schools

, 2016
Standardized testing provides an important means to measure students’ performance relative to their peers and grade-level learning objectives. Over the past twenty years or so, the use of results from standardized testing has been expanded as a measure ...
Destremps, Samantha
core  

Teaching to the test: A very large red herring

Nonpartisan Education Review, 2016
Elevating teaching-to-the-test to dogma, from the beginning with the distortion of Dr. Cannell’s findings, has served to divert attention from scandals that should have threatened US educators’ almost complete control of their own evaluation.[10] Had the
Richard P. Phelps
doaj