Results 111 to 120 of about 7,059,629 (302)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Corporate sustainability reporting is increasingly scrutinised as stakeholders’ demand credible commitments to environmental and social performance, especially in sectors where unsustainable practices are pervasive. The aim of this research is to examine—
Julia Marques de Medeiros +4 more
doaj +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The demand for family nurse practitioners (FNPs) continues to rise, yet inconsistencies in clinical education have led to significant variability in graduate preparedness.
Jessica Nishikawa, Tandrea Jackson
doaj +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
A Proposal for a Retrofit Master’s Degree in University Education: Bridging the Skill Gap
Retrofitting the UK building stock is a key priority due to the importance of achieving sustainability goals, preferably before 2050. This goal will not be achieved without reducing energy consumption and making houses more comfortable, healthier, and ...
Chamara Panakaduwa +4 more
doaj +1 more source
Interoperability standards for cloud architecture [PDF]
Enabling cloud infrastructures to evolve into a transparent platform raises interoperability issues. Interoperability requires standard data models and communication technologies compatible with the existing Internet infrastructure.
Fowley, Frank, Pahl, Claus, Zhang, Li
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Globalization and a Green Computing Policy Framework
With globalization rising, much scholarship has presented “a race to the bottom” regarding standards posing serious environmental concerns. This paper considers the debate of globalization leading to a “race to the bottom” or, contrastingly, a “race to ...
Ted Peterson
doaj +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source

