Results 41 to 50 of about 6,063,674 (258)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Differences between European birthweight standards: impact on classification of ‘small for gestational age’ [PDF]
, 2006 We describe a quantitative and comparative review of a selection of European birthweight standards for gestational age for singletons, to enable appropriate choices to be made for clinical and research use.
Glinianaia, S. V. +4 more
core +1 more source
ALT-J, 1993 One of the aims of ALT is to promote good practice in the use of learning technology within higher education. Few would not subscribe to this aim, but proclaiming it without a full awareness of the problems it entails is of the same order as proclaiming one's commitment to Peace without further comment.
openaire +4 more sources
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Raising standards and tackling workload: a national agreement: time for standards [PDF]
, 2003 "This document represents an historic national Agreement between Government, employers and school workforce unions to help schools, teachers and support staff meet the challenges that lie ahead.
core
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Living standards during previous recessions [PDF]
, 2009 The current recession is the first that the UK has experienced since the early 1990s. Much has changed since then, and society's collective memory of who fared worst during previous recessions seems likely to have faded.
Muriel, A., Sibieta, L.
core +1 more source
No Standard for Standards: Understanding the ICT Standards Development Ecosystem
SSRN Electronic Journal, 2016 There is no standard for standards. Technology standards are created, maintained and propagated in a bewildering variety of ways, by a diverse set of actors. This Chapter attempts to explain this ironic and complex reality, and to provide a framework for understanding different standards development models in the information and communications ...
openaire +4 more sources
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source