Results 11 to 20 of about 9,334 (177)

Delivery of Pleckstrin-Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis. [PDF]

Adv Sci (Weinh)
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Eason M, Sen A, Cho S, Lee SJ, Thompson K, Mahmud MM, Dubey P, Guardia T, Kim A, Martin S, Wright N, Konstantopoulos K, Kontrogianni-Konstantopoulos A.   +12 more
europepmc   +2 more sources

Core Outcome Set-STAndardised Protocol Items: The COS-STAP Statement [PDF]

, 2019
Background: Several hundred core outcome set (COS) projects have been systematically identified to date which, if adopted, ensure that researchers measure and report those outcomes that are most likely to be relevant to users of their research.
Cos-Stap Group,, Jane M. Blazeby, Williamson, Paula R, Mike Clarke, Paula R. Williamson, for the COS-STAP Group, Blazeby, JM, Tunis, S R, Sarah Gorst, Altman, DG, Sean Tunis, Gorst, Sarah, Blazeby, Jane, Williamson, Paula, Jamie J. Kirkham, Tunis, S, Douglas G. Altman, Altman, Douglas, Kirkham, JJ, Kirkham, Jamie J, Gorst, S, ?, ?, Williamson, PR, Clarke, M, Group,, Cos-Stap   +24 more
core   +2 more sources

Possible Therapeutic Applications of Targeting STAP Proteins in Cancer [PDF]

, 2021
The signal-transducing adaptor protein (STAP) family, including STAP-1 and STAP-2, contributes to a variety of intracellular signaling pathways. The proteins in this family contain typical structures for adaptor proteins, such as Pleckstrin homology in ...
Matsuda, Tadashi, Oritani, Kenji
core   +1 more source

Knowledge-aided STAP in heterogeneous clutter using a hierarchical bayesian algorithm [PDF]

, 2011
This paper addresses the problem of estimating the covariance matrix of a primary vector from heterogeneous samples and some prior knowledge, under the framework of knowledge-aided space-time adaptive processing (KA-STAP).
Bidon, Stéphanie, Stephanie Bidon, Jean-Yves Tourneret, Besson, Olivier, Olivier Besson, Tourneret, Jean-Yves   +5 more
core   +1 more source

Brk phosphorylates and regulates STAP-2 functions [PDF]

, 2009
Signal transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains Pleckstrin and Src homology 2 (SH2)-like domains as well as a YXXQ motif in its C-terminal region.
Sekine, Yuichi, Ikeda, Osamu, Matsuda, Tadashi, Muromoto, Ryuta, Miyasaka, Yuto, Yoshimura, Akihiko, Mizushima, Akihiro, Nanbo, Asuka   +7 more
core   +1 more source

Cbl controls STAP-2 activity through protein degradation [PDF]

, 2009
Signal transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2 (SH2)-like domains as well as a YXXQ motif in its C-terminal region. Our previous study in T cells demonstrated that STAP-2
Sekine, Yuichi, Ikeda, Osamu, Matsuda, Tadashi, Muromoto, Ryuta, Yoshimura, Akihiko, Oritani, Kenji, Yamamoto, Chikako, Nanbo, Asuka   +7 more
core   +1 more source

Doppler compensation in forward-looking STAP radar

, 2022
S.253-258For air- and spaceborne MTI radar the clutter Doppler frequency depends on range for all array geometries other than linear sidelooking. This applies particularly to forward-looking arrays.
Klemm, R., Kreyenkamp, O.
core   +1 more source

Afbakening arbeidsmarktgerichtheid niet-OCW erkende scholing voor STAP regeling [PDF]

, 2021
Werkenden en werkzoekenden kunnen vanaf 1 maart 2022 een STAP-budget van maximaal 1000 Euro aanvragen voor scholing en ontwikkeling. STAP staat voor Stimulering ArbeidsmarktPositie. Met het STAP-budget wil de overheid mensen helpen om zich te ontwikkelen
Montizaan, Raymond, Künn, Annemarie
core   +1 more source

Adaptive monopulse with STAP

, 2022
S.1-4Monopulse is a well known technique for high accuracy estimation of target parameters such as azimuth and elevation as well as the radial velocity.
Klemm, R., Nickel, U.
core   +1 more source

STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis [PDF]

, 2012
In chronic myeloid leukemia (CML), the BCR-ABL fusion oncoprotein activates multiple pathways involved in cell survival, growth promotion and disease progression.
Kanakura, Y., Yoshimura, A., Sekine, Y., Ikeda, O., Ueno, Y., Mizushima, A., Muromoto, R., Oritani, K., Matsuda, T.   +8 more
core   +1 more source