Results 191 to 200 of about 126,096 (348)

Accessibility and Alignment of Trans‐Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein

Angewandte Chemie, EarlyView.
Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu, Wei Feng, Hongquan Zhang, X. Chris Le   +3 more
wiley   +2 more sources

The Mixed Neutrophilic–Eosinophilic Endotype of CRSwNP Blunts Postsurgical Improvement as Determined by the Completeness of Surgery Index

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The Completeness of Surgery Index (CoSI) is a novel metric for assessing surgical quality in chronic rhinosinusitis with nasal polyps (CRSwNP). Structured histopathology (SHP) is helpful for characterizing drivers of inflammation. Integrating these two tools to identify patients at higher risk for surgically recalcitrant disease has
Vidit M. Talati, Kerol Faltas, Michael R. Xiang, Randy Bach, Spencer L. Yueh, Margaret B. Mitchell, Alan D. Workman, Michael A. Kohanski, Nithin D. Adappa, Jennifer E. Douglas, Noam A. Cohen, John V. Bosso, James N. Palmer   +12 more
wiley   +1 more source

Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance

Angewandte Chemie, EarlyView.
The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato, Hannah Hunter, Sadhana Srinivasa, Chang‐Hyeock Byeon, Abdulkadir Tunc, Meghan K. Wells, Faith J. Scott, Frederic Mentink‐Vigier, Wook Kim, Sunil Saxena, Ümit Akbey   +10 more
wiley   +2 more sources

A fluorogenic biotracer for reliable detection of staphylococcal beta-lactamase: towards improved precision therapy in severe MSSA infections. [PDF]

J Antimicrob Chemother
Dupieux C, Martins Simoes P, Youenou B, Vandenesch F, Tristan A, Laurent F.   +5 more
europepmc   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources

Bedbugs as Vectors for Drug-Resistant Bacteria

Emerging Infectious Diseases, 2011
Christopher F. Lowe, Marc G. Romney
doaj   +1 more source

Changes in observed bloodstream infection epidemiology during a single-set blood culture restriction: an interrupted time series analysis. [PDF]

J Clin Microbiol
Ladines-Lim JB, Van B, Cressman L, Bilker WB, Degnan KO, David MZ.   +5 more
europepmc   +1 more source

Phenotypic Associations in Resistance to Medically Important Antibiotics Among Highly Resistant Bacteria Isolated from Cambodian Dairy Farms. [PDF]

Biology (Basel)
Dim K, Nakamura S, Rin S, Nouv S, Na S, Sokhom P, Matsuyama S, Ohkura S, Suriyasathaporn W.   +8 more
europepmc   +1 more source

Microbial Contamination of Radiology Equipment: A Descriptive Study in Ghana. [PDF]

Health Sci Rep
Angmorterh SK, Deku JG, Akyea-Mensah E, de Venter RV, Amu H, Aboagye S, Agyemang PN, Angaag NA, Kenyanya JO, Kekessie KK, Klugah-Brown B.   +10 more
europepmc   +1 more source

Microbiota and Cheese Quality. [PDF]

Foods
Centeno JA, Carballo J.
europepmc   +1 more source