Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection
New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim+9 more
wiley +1 more source
Antibiotic resistance in the environment, with particular reference to MRSA [PDF]
The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine.
Aarestrup+171 more
core +1 more source
Biofilm-associated polymicrobial infections tend to be challenging to treat. Candida albicans and Staphylococcus aureus are leading pathogens due to their ability to form biofilms on medical devices.
Taissa Vila+7 more
doaj +1 more source
Characterization of Methicillin-resistant Staphylococcus aureus Isolates from Fitness Centers in Memphis Metropolitan Area, USA [PDF]
Indoor skin-contact surfaces of public fitness centers may serve as reservoirs of potential human transmission of methicillin-resistant Staphylococcus aureus (MRSA). We found a high prevalence of multi-drug resistant (MDR)-MRSA of CC59 lineage harboring a variety of extracellular toxin genes from surface swab samples collected from inanimate surfaces ...
arxiv
A meta-analysis was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia. A search of the MEDLINE database for studies published during the period of 1 January 1980 through 31 December 2000 and a ...
S. Cosgrove+5 more
semanticscholar +1 more source
A hollow‐structured Fe3O4@AgAu@PDA‐ZnPc nanosphere has been developed, exhibiting controllable catalytic activity and “photothermal‐photodynamic‐Ag+” coupling antibacterial characteristics. When subjected to a rotating magnetic field, these performances are uniquely enhanced by magnetic propulsion, allowing the nanosphere to function as a magnetic ...
Jing Wang+7 more
wiley +1 more source
KOLONISASI BAKTERI PATOGEN POTENSIAL PENYEBAB INFEKSI DAERAH OPERASI PADA KULIT PASIEN PRAOPERATIF [PDF]
Backgroud : Surgical Site Infection (SSI) is associated with mortality and morbidity in hospital. The most common pathogen that caused SSI are Staphylococcus aureus, Escherichia coli, Enterobacter sp, Pseudomonas sp. , and Klebsiella sp.
Farida, Helmia+2 more
core
High potency of melaleuca alternifolia essential oil against multi-drug resistant gram-negative bacteria and methicillin-resistant staphylococcus aureus [PDF]
Purpose: Herein, an extended investigation of Tea tree oil (TTO) against a number of multi-drug resistant (MDR) microorganisms in liquid and vapor phases is reported.
Božović, Mijat+7 more
core +1 more source
Intracellular adhesion gene expression studies in biofilm-forming of Staphylococcus aureus isolated from different clinical sources in Bagdad, Iraq [PDF]
Background: Staphylococcus aureus (S. aureus) a pathogenic bacterium typically found in the population is noteworthy for its pathogenicity due to its ability to produce biofilms with high virulence.
Susan Khadhem, Yaseen Motea
doaj +1 more source
Genetic transfer in Staphylococcus: a case study of 13 genomes [PDF]
The widespread presence of antibiotic resistance and virulence among Staphylococcus isolates has been attributed to lateral genetic transfer (LGT) between different strains or species. However, there has been very little study of the extent of LGT in Staphylococcus species using a phylogenetic approach, particularly of the units of such genetic ...
arxiv