Results 111 to 120 of about 379,097 (314)

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

open access: yesAdvanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi   +8 more
wiley   +1 more source

NIR Driven Pd/Cerium Oxide Nano‐Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy

open access: yesAdvanced Science, EarlyView.
In vivo SALI therapy is achieved by scavenging intracellular ROS levels, downregulating inflammatory factors expression levels, inducing macrophage M2 directional polarization, and activating Keap1/Nrf‐2/HO‐1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation, and promote liver tissue repair. Abstract Sepsis
Tao Qin   +21 more
wiley   +1 more source

The Environmental Distribution of Staphylococcus Aureus in an Operating Suite

open access: green, 1959
Robert I. Wise   +3 more
openalex   +2 more sources

Red Blood Cell‐Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell‐Depleted Thrombi, Restoring Severe Bacteremia in Rats

open access: yesAdvanced Science, EarlyView.
A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang   +4 more
wiley   +1 more source

Osteomyelitis: an overview of antimicrobial therapy

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2013
Osteomyelitis is an inflammatory bone disorder caused by infection, leading to necrosis and destruction of bone. It can affect all ages, involve any bone, become a chronic disease and cause persistent morbidity.
Diana Gomes   +2 more
doaj  

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

open access: yesAdvanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li   +11 more
wiley   +1 more source

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