Results 171 to 180 of about 105,629 (308)

Elexacaftor–Tezacaftor–Ivacaftor Improves Sinonasal Outcomes in Young Children With Cystic Fibrosis

open access: yesInternational Forum of Allergy &Rhinology, Volume 15, Issue 7, Page 706-714, July 2025.
ABSTRACT Background Severe chronic rhinosinusitis (CRS) is a near universal manifestation of cystic fibrosis. Elexacaftor/tezacaftor/ivacaftor (ETI) is an oral, small molecule, highly effective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) corrector–potentiator drug.
Amanda L. Stapleton   +10 more
wiley   +1 more source

Disruption of salt bridge interactions in the inter‐domain cleft of the tubulin‐like protein FtsZ of Escherichia coli makes cells sensitive to the cell division inhibitor PC190723

open access: yesCytoskeleton, Volume 82, Issue 7, Page 415-431, July 2025.
Abstract FtsZ forms a ring‐like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into two halves, indicating its importance in bacterial cell division. FtsZ is an attractive target for developing new anti‐microbial drugs to overcome the challenges of antibiotic ...
Sakshi Mahesh Poddar   +3 more
wiley   +1 more source

Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potential Target

open access: yesChemMedChem, Volume 20, Issue 13, July 1, 2025.
Quinazolinone‐based compounds emerge as potent antimycobacterial agents, showing low minimum inhibitory concentrations against drug‐resistant Mycobacterium tuberculosis. Molecular modeling uncovers a novel allosteric site in PonA1 targeted by these derivatives.
Marek Kerda   +15 more
wiley   +1 more source

Exploring the Multifaceted Potential of Elaeagnus angustifolia L.: A Comprehensive Review of Its Nutritional, Pharmacological, and Environmental Significance

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
Elaeagnus angustifolia is a resilient, multi‐purpose plant valued for its roles in food, medicine, fuel, and environmental protection. This review highlights its rich biochemical composition and therapeutic properties, including antioxidant, anti‐inflammatory, and wound‐healing effects.
Muhammad Abubakkar Azmat   +4 more
wiley   +1 more source

Insect Lipids as Novel Source for Future Applications: Chemical Composition and Industry Applications—A Comprehensive Review

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
Fat body (FB) acts as a major metabolic center important for the regulation of a variety of physiological processes such as embryogenesis, reproduction, flight, overwintering, protection, and communication. Lipid amounts and fatty acid (FA) composition vary with species, stage of life, and their diet.
Shahida Anusha Siddiqui   +2 more
wiley   +1 more source

Antimicrobial Susceptibility Patterns of Uropathogens: A Retrospective Study at a Primary Care Hospital in Ghana

open access: yesHealth Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Urinary tract infections are among the most common infections globally, with increasing rates of antibiotic resistance complicating their management. This study aimed to determine the prevalence, bacteriological profile, and antibiotic susceptibility patterns of uropathogens isolated from urine samples at Methodist Hospital,
Samuel Kyeremeh Adjei, Prosper Adjei
wiley   +1 more source

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