Results 91 to 100 of about 463,138 (331)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Isolation and Characterization of New Bacteriophages against Staphylococcal Clinical Isolates from Diabetic Foot Ulcers

Viruses, 2023
Staphylococcus sp. is the most common bacterial genus in infections related to diabetic foot ulcers (DFUs). The emergence of multidrug-resistant bacteria places a serious burden on public health systems.
Lucile Plumet, Madjid Morsli, Nour Ahmad-Mansour, Fernando Clavijo-Coppens, Laurence Berry, Albert Sotto, Jean-Philippe Lavigne, Denis Costechareyre, Virginie Molle   +8 more
doaj   +1 more source

Experimental phage therapy of burn wound infection : difficult first steps [PDF]

, 2014
Antibiotic resistance has become a major public health problem and the antibiotics pipeline is running dry. Bacteriophages (phages) may offer an ‘innovative’ means of infection treatment, which can be combined or alternated with antibiotic therapy and ...
De Vos, Daniel, Jennes, Serge, Lavigne, Rob, Merabishvili, Maia, Pirnay, Jean Paul, Rose, Thomas, Vaneechoutte, Mario, Verbeken, Gilbert, Zizi, Martin   +8 more
core  

Mobilisation Mechanism of Pathogenicity Islands by Endogenous Phages in Staphylococcus aureus clinical strains

Scientific Reports, 2018
Staphylococcus aureus pathogenicity islands (SaPIs) are a type of mobile genetic element that play a significant role in the pathogenesis and virulence of this microorganism.
M. Cervera-Alamar, Katerina Guzmán-Markevitch, M. Žiemytė, L. Ortí, P. Bernabé-Quispe, A. Pineda-Lucena, J. Pemán, M. A. Tormo‐Mas   +7 more
semanticscholar   +1 more source

Bacteriophages Combined With Subtherapeutic Doses of Flucloxacillin Act Synergistically Against Staphylococcus aureus Experimental Infective Endocarditis

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2022
Background The potential of phage therapy for the treatment of endovascular Staphylococcus aureus infections remains to be evaluated. Methods and Results The efficacy of a phage cocktail combining Herelleviridae phage vB_SauH_2002 and Podoviriae phage 66
J. Save, Y. Que, J. Entenza, C. Kolenda, F. Laurent, G. Resch   +5 more
semanticscholar   +1 more source

Staphylococcus aureus strains of phage-group IV [PDF]

Epidemiology and Infection, 1967
Because the international basic set of staphylococcus typing phages includes only one member of group IV—phage 42 D—the group is insufficiently characterized. This set of phages is therefore not suitable for typing bovine strains of Staph. aureus. The addition of several further group IV phages would remedy this deficiency.
openaire   +2 more sources

SMart Nanoparticle–Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing

Advanced Science, EarlyView.
The integrated system, comprising bacterial‐targeted photothermal nanoparticles (Fe2O3‐CS@RBP) and multifunctional hydrogels (PAOC‐3@BA) modules, achieves rapid wound healing within one week. This work introduces a smart therapeutic platform that integrates bacterial targeting, self‐regulating photothermal therapy, tissue adhesion, and stimulus ...
Hongping Wan, Huirong Tan, Xinghong Zhao
wiley   +1 more source

CHARACTERISTIC OF SENSITIVITY TO ANTIBIOTICS AND PHAGES OF STAPHYLOCOCCI STRAINS, ISOLATED FROM MICE REPRODUCTIVE TRACT

Patologìâ, 2014
Aim. To study the characteristic of sensitivity to antibiotics and phages of staphylococci strains, isolated from mice reproductive tract. Methods and results. Isolated from the mice vagina staphylococci strains were identified as species S. aureus, S.
T. N. Shevchenko, O. S. Voronkova, A. I. Vinnikov   +2 more
doaj   +1 more source

APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting Staphylococcus aureus and MRSA Biofilms

International Journal of Molecular Sciences, 2022
The high infection and mortality rate of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the urgent development of new treatment strategies.
Shan Liu, K. Hon, G. Bouras, A. Psaltis, K. Shearwin, P. Wormald, S. Vreugde   +6 more
semanticscholar   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

Advanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi, Renliang Zhao, Jia Wang, Zhenchen Xiong, Xiangtian Deng, Cheng Zheng, Wenzhi Zhang   +6 more
wiley   +1 more source