Results 141 to 150 of about 24,475 (286)

Microbial amyloids in neurodegenerative amyloid diseases

The FEBS Journal, Volume 292, Issue 6, Page 1265-1281, March 2025.
Numerous microbes, including those indigenous to the human microbiome, produce amyloidogenic proteins. These proteins have critical functions in bacterial physiology and their lifestyles. Emerging evidence indicates that microbial amyloids also interact directly or indirectly with host‐derived amyloid proteins, such as those which underlie Parkinson's ...
Timothy Sampson
wiley   +1 more source

High throughput platform technology for rapid target identification in personalized phage therapy

Nature Communications
As bacteriophages continue to gain regulatory approval for personalized human therapy against antibiotic-resistant infections, there is a need for transformative technologies for rapid target identification through multiple, large, decentralized ...
Fereshteh Bayat, Arwa Hilal, Mathura Thirugnanasampanthar, Denise Tremblay, Carlos D. M. Filipe, Sylvain Moineau, Tohid F. Didar, Zeinab Hosseinidoust   +7 more
doaj   +1 more source

Bacteriophages benefit from generalized transduction.

PLoS Pathogens, 2019
Temperate phages are bacterial viruses that as part of their life cycle reside in the bacterial genome as prophages. They are found in many species including most clinical strains of the human pathogens, Staphylococcus aureus and Salmonella enterica ...
Alfred Fillol-Salom, Ahlam Alsaadi, Jorge A Moura de Sousa, Li Zhong, Kevin R Foster, Eduardo P C Rocha, José R Penadés, Hanne Ingmer, Jakob Haaber   +8 more
doaj   +1 more source

Mechanisms of Multi-strain Coexistence in Host-Phage Systems with Nested Infection Networks [PDF]

arXiv, 2013
Bacteria and their viruses ("bacteriophages") coexist in natural environments forming complex infection networks. Recent empirical findings suggest that phage-bacteria infection networks often possess a nested structure such that there is a hierarchical relationship among who can infect whom.
arxiv  

Membrane selectivity and pore formation of SprA1 and SprA2 hemolytic peptides from Staphylococcus aureus type I toxin–antitoxin systems

The FEBS Journal, EarlyView.
When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon, Noëlla Germain‐Amiot, Charlotte Oriol, Astrid Rouillon, Yoann Augagneur, Stéphane Dréano, Irène Nicolas, Alexandre Chenal, Arnaud Bondon, Soizic Chevance, Marie‐Laure Pinel‐Marie   +10 more
wiley   +1 more source

Genomic analyses of two novel biofilm-degrading methicillin-resistant Staphylococcus aureus phages

BMC Microbiology, 2019
Background Methicillin-resistant Staphylococcus aureus (MRSA) biofilm producers represent an important etiological agent of many chronic human infections.
Khulood Hamid Dakheel, Raha Abdul Rahim, Vasantha Kumari Neela, Jameel R. Al-Obaidi, Tan Geok Hun, Mohd Noor Mat Isa, Khatijah Yusoff   +6 more
doaj   +1 more source

PHAGE FORMATION IN STAPHYLOCOCCUS MUSCAE CULTURES [PDF]

, 1952
Winston H. Price
openalex   +1 more source

Characterization and ex vivo modelling of endodontic infections from the Arabian Gulf region

International Endodontic Journal, EarlyView.
Abstract Aim The microbiota of endodontic infections in patients from the Arabian Gulf region (AGR) is largely unexplored. While research in different global regions has investigated the microbial composition of such infections, studies using shotgun metagenomic sequencing (SMS) alongside culture‐dependent techniques (CDT) are limited.
Rania Nassar, Mohannad Nassar, Lobna Mohamed, Abiola Senok, David Williams   +4 more
wiley   +1 more source

Incomplete prophage tolerance by type III-A CRISPR-Cas systems reduces the fitness of lysogenic hosts

Nature Communications, 2018
CRISPR-Cas systems, such as type III-A CRISPR-Cas, provide an immune mechanism for prokaryotic hosts to resist parasites, including phages. Here, the authors show that maintenance of conditionally tolerant type III-A systems can affect the fitness of ...
Gregory W. Goldberg, Elizabeth A. McMillan, Andrew Varble, Joshua W. Modell, Poulami Samai, Wenyan Jiang, Luciano A. Marraffini   +6 more
doaj   +1 more source

Rapid Identification of Intact Staphylococcal Bacteriophages Using Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry

Viruses, 2018
Staphylococcus aureus is a major causative agent of infections associated with hospital environments, where antibiotic-resistant strains have emerged as a significant threat.
Dana Štveráková, Ondrej Šedo, Martin Benešík, Zbyněk Zdráhal, Jiří Doškař, Roman Pantůček   +5 more
doaj   +1 more source