Results 51 to 60 of about 5,349 (162)

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Exploring the role of low‐dose atropine in myopia management in children with inherited retinal diseases

Optometry and Vision Science, Volume 103, Issue 4, April 2026.
ABSTRACT Purpose This study aimed to evaluate the effectiveness of low‐dose atropine in slowing myopic progression in children with inherited retinal diseases (IRDs) and myopia. Methods Retrospective study of children with IRDs, comparing myopia progression between those who received atropine drops and those who did not was conducted.
Rotem Azmon, Asaf Kreindler, Ben Ezra Kahtan, Irit Knisbacher, Melanie Mysler, Miriam Ehrenberg, Karen Hendler, Samer Khateb, Claudia Yahalom   +8 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Soluble epoxide hydrolase (sEH) inhibition enhances corneal wound healing following alkali injury. (A) Schematic representation of corneal injury induced by NaOH or ammonia showing elevated sEH expression in corneal keratocytes. This leads to rapid hydrolysis of epoxy fatty acids (EpFAs), reducing their bioavailability and contributing to enhanced ...
Xiaowen Lu, Christophe Morisseau, Khushi Jain, Zhong Chen, Amy J. Estes, Darryl Zeldin, Artiom Gruzdev, Aniqa Ahmed, Haley Cook, Bruce D. Hammock, Mitchell A. Watsky   +10 more
wiley   +1 more source

The height of the posterior staphyloma and corneal hysteresis is associated with the scleral thickness at the staphyloma region in highly myopic normal-tension glaucoma eyes

, 2018
Aims To evaluate the characteristics of the posterior segments of eyes with high myopia and normal-tension glaucoma (NTG) and identify which ocular factors are most associated with scleral thickness and posterior staphyloma height.
최규룡
core   +1 more source

OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu, An Shao, Bingtao Guan, Ziyao Luo, Weiyi Lai, Xiaoling Huang, Jun Liu, Jie Yan, Huimin Li, Xiangji Pan, Jiawei Wang, Zichang Su, Yih Chung Tham, Jie Yang, Haotian Lin, Juan Ye, Hongxia Xu, Jian Wu   +17 more
wiley   +1 more source

Implantation of a Trifocal Intraocular Lens in High Myopic Eyes with Nasal-Inferior Staphyloma

Clinical Ophthalmology, 2020
Belén Alfonso-Bartolozzi,1 Eva Villota,1 Álvaro Fernández-Vega-González,1 Luis Fernández-Vega-Cueto,1 Álvaro Fernández-Vega,1 José F Alfonso1,2 1Fernández-Vega Ophthalmological Institute ...
Alfonso-Bartolozzi B, Villota E, Fernández-Vega-González Á, Fernández-Vega-Cueto L, Fernández-Vega Á, Alfonso JF   +5 more
doaj  

A Case of Knobloch Syndrome With Lens Dislocation Resembling Homocystinuria

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT We report a 39‐year‐old woman with lifelong visual impairment who presented in June 2024 with progressive visual deterioration in her right eye. Ophthalmologic evaluation revealed severe high myopia, vitreoretinal degeneration, phthisis bulbi of the left eye, and downward lens dislocation of the right eye.
Elnaz Asadollahzadeh, Ali Rezaei, Vahid Shahmaei, Mohammad‐Sadegh Johari, Mohammad Ali Sahraian   +4 more
wiley   +1 more source

Ciliary Defects in Inherited Retinal Diseases

Advanced Genetics, Volume 7, Issue 1, March 2026.
The photoreceptor cilium is a specialized sensory organelle essential for vision. This review systematically summarizes the structural and functional defects of the cilium that lead to inherited retinal diseases (IRDs). It highlights key pathogenic genes, elucidates molecular mechanisms of degeneration, and evaluates emerging therapeutic strategies ...
Guizhi Guo, Lin Li, Jun Zhou, Jie Ran
wiley   +1 more source

Prevalence of posterior staphyloma and factors associated with its shape in the Japanese population [PDF]

, 2018
Myopia is increasing rapidly worldwide. We performed a cross-sectional study to investigate the prevalence of posterior staphyloma, a complication of myopia, and its shape characteristics in relation to age, sex, and axial length (AL) in a Japanese ...
Yoshimitsu Takahashi, Nakanishi, Hideo, Kenji Yamashiro, Matsuda, Fumihiko, Hideo Nakanishi, Oishi, Akio, Tabara, Yasuharu, Takahisa Kawaguchi, Akitaka Tsujikawa, Setoh, Kazuya, Kosugi, Shinji, Numa, Shogo, Takahashi, Yoshimitsu, Nagahisa Yoshimura, Nakayama, Takeo, Munemitsu Yoshikawa, Fumihiko Matsuda, Akio Oishi, Yoshikawa, Munemitsu, Shinji Kosugi, Wakazono, Tomotaka, Tsujikawa, Akitaka, Shogo Numa, Miyake, Masahiro, Yoshimura, Nagahisa, Kazuya Setoh, null null, Tomotaka Wakazono, Yasuharu Tabara, Yamashiro, Kenji, Takeo Nakayama, Masahiro Miyake, Kawaguchi, Takahisa   +32 more
core   +1 more source

Clinical and Genetic Characteristics of Free Sialic Acid Storage Disorder

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Free sialic acid storage disorder (FSASD) is a lysosomal storage disorder that results from biallelic pathogenic variants in the SLC17A5 gene. This gene codes for sialin, a 12‐transmembrane domain protein that exports the charged sugar N‐acetylneuraminic acid (Neu5Ac; sialic acid) out of the lysosome.
Zoe Wolfenson, Gabriella Grois, Ruth F. Hailemeskel, Marla Sabaii, Laryssa A. Huryn, Wadih M. Zein, Tanya Lehky, Audrey Thurm, Lisa Joseph, Eva H. Baker, Gilbert Vezina, Keith Hyland, Laura Pollard, Ellen Macnamara, Andrea Gropman, May C. Malicdan, William A. Gahl, David R. Adams, Lynne Wolfe   +18 more
wiley   +1 more source