Results 111 to 120 of about 4,162,760 (300)

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Young Stellar Objects in the Carina Nebula: Near-infrared Variability and Spectroscopy

The Astronomical Journal
We present a catalog of 652 young stellar objects (YSOs) in the Carina star-forming region. The catalog was constructed by combining near-infrared K _S -band variability from the VISTA Variables in the Vía Láctea eXtended survey and medium-resolution H ...
Jura Borissova, Radostin Kurtev, Josemanuel Escobar, Javier Alonso-García, Nicolas Medina, Javier Osses, Zhen Guo, Philip W. Lucas, Michael Kuhn, Dante Minniti, Kevin R. Covey, Roberto K. Saito, Francisco Förster   +12 more
doaj   +1 more source

The S-PLUS Fornax Project (S+FP): An extragalactic catalog covering ∼5 virial radii around NGC1399 with galaxy properties

Astronomy & Astrophysics
Context. Observational extragalactic catalogs over wide sky areas are essential for uncovering the large-scale structure of the Universe. They allow, among other things, cosmological studies and density analyses that impose strong constraints on models ...
Haack R. F., Smith Castelli A. V., Sodré L., Mendes de Oliveira C., Lopes A. R., Gutiérrez-Soto L. A., Demarco R., Olave-Rojas D. E., Carrasco E. R., Humire P. K., Calderón J. P., de Almeida Fernandes F., Lomelí-Núñez L., Sepúlveda G., Lima-Dias C., Torres Flores S., Telles E., Cardoso N. M., Palma D., Doubrawa L., Pallero D., Marinello M., Schoenell W., Ribeiro T., Kanaan A.   +24 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Sierra Club, Lone Star Chapter Newsletter

, 2019
Newsletter from the Lone Star Chapter of Sierra Club regarding Big Thicket Committee with an article titled "Big Thicket Expansion Sought" from the Lone Star SierranThe Big Thicket Collection contains materials relating to the conservation of the Big ...
Sierra Club, Lone Star Chapter
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

JWST Observations of Starbursts: Massive Star Clusters in the Central Starburst of M82

The Astrophysical Journal Letters
We present a near-infrared (NIR) candidate star cluster catalog for the central kiloparsec of M82 based on new JWST NIRCam images. We identify star cluster candidates using the F250M filter, finding 1357 star cluster candidates with stellar masses >10 ^4
Rebecca C. Levy, Alberto D. Bolatto, Divakara Mayya, Bolivia Cuevas-Otahola, Elizabeth Tarantino, Martha L. Boyer, Leindert A. Boogaard, Torsten Böker, Serena A. Cronin, Daniel A. Dale, Keaton Donaghue, Kimberly L. Emig, Deanne B. Fisher, Simon C. O. Glover, Rodrigo Herrera-Camus, María J. Jiménez-Donaire, Ralf S. Klessen, Laura Lenkić, Adam K. Leroy, Ilse De Looze, David S. Meier, Elisabeth A. C. Mills, Juergen Ott, Mónica Relaño, Sylvain Veilleux, Vicente Villanueva, Fabian Walter, Paul P. van der Werf   +27 more
doaj   +1 more source