Results 191 to 200 of about 24,866 (298)

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

RSONAR: Data-Driven Evaluation of Dual-Use Star Tracker for Stratospheric Space Situational Awareness (SSA). [PDF]

Sensors (Basel)
Suthakar V, Porto I, Myhre M, Sanvido AA, Clark R, Lee RSK.   +5 more
europepmc   +1 more source

Catalog of outbursts of neutron star LMXBs

Many X-ray binaries are transiently accreting. Having statistics on their recurrence times is helpful to address questions related to binary evolution and populations, as well as the physics of binary systems.
Maccarone, Thomas J., Zheng, Junwen, Bahramian, Arash, Sivakoff, Gregory R., Heinke, Craig O., Degenaar, Nathalie   +5 more
core  

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cellsduring Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

Therapeutic Potential of Cannabinoids in Attenuating Amiodarone-Induced Pulmonary Fibrosis: An in vivo Experimental Study in Wistar Rats. [PDF]

Drug Des Devel Ther
Almalki RS.
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Protocol for isolating and assessing immunomodulatory ability of explant-cultured human amniotic membrane mesenchymal stem cells. [PDF]

STAR Protoc
Dutta Gupta S, Banerjee P, Haoladar T, Aparajeet A, Ta M.   +4 more
europepmc   +1 more source

Bridging Low- and High-Mass Star Formation with an Expanded Yellowball Catalog

Understanding star formation is critical to understanding the evolution and history of galaxies and, by extension, how our universe came to be the way it is. “Yellowballs,” or YBs, are sites of star formation in our Milky Way Galaxy.
Devine, Kathryn, Kerton, Charles, Larose, Nick, Bassingthwaite, Ethan, Wolf-Chase, Grace, Coleman, Michael   +5 more
core  

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

An expanded reference catalog of translated open reading frames for biomedical research. [PDF]

Nucleic Acids Res
Chothani S, Ruiz-Orera J, Tierney JAS, Swirski MI, Tjeldnes H, Kok LW, Clauwaert J, Deutsch EW, Alba MM, Aspden JL, Baranov PV, Bazzini AA, Bruford EA, Brunet MA, Cardon T, Carvunis AR, Casola C, Choudhary JS, Dean K, Faridi P, Fierro-Monti I, Fournier I, Frankish A, Gerstein M, Hubner N, Jiang Y, Kellis M, Martinez TF, Menschaert G, Ni P, Orchard S, Roucou X, Rozowsky J, Salzet M, Siragusa M, Slavoff S, Ternette N, Vizcaino JA, Wacholder A, Wu W, Xie Z, Yang YT, Moritz RL, Valen E, Mudge J, van Heesch S, Prensner JR, Rackham OJL.   +47 more
europepmc   +1 more source