Results 181 to 190 of about 4,162,760 (300)
Global satellite analysis reveals landslide susceptibility peaks at intermediate vegetation density. [PDF]
iScienceYuan S +8 more
europepmc +1 more source
Advanced Science, EarlyView.Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng +14 more
wiley +1 more source
Protecting Against Cytoplasmic Protein Aggregates With Cytoplasmic PML Variants. [PDF]
Bio ProtocZhu JX +5 more
europepmc +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Performance Evaluation, Optical Optimization and Earth-Based Validation of Star Sensors for Ground Detection in Martian Dust Environments. [PDF]
Sensors (Basel)Gao Y +5 more
europepmc +1 more source
A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment
Advanced Science, EarlyView.MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu +15 more
wiley +1 more source
EPHA2 and WNT reciprocally regulate MAPK-dependent gene expression in a pancreatic cancer model. [PDF]
JCI InsightWadia SR +6 more
europepmc +1 more source
Advanced Science, EarlyView.A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang +8 more
wiley +1 more source