Results 221 to 230 of about 4,162,760 (300)

Polycomb factor PHF19 affects AML initiation, patient prognosis, and survival. [PDF]

Sci Adv
Gamarra Figueroa GP, Gutierrez A, Blanco E, Vizán P, Ballaré C, Sparavier A, Tosto M, Minucci S, Velten L, Di Croce L.   +9 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Identification and Functional Characteristics of <i>NR5A1</i> Gene Variant in Patients with 46,XY Disorders of Sex Development. [PDF]

Genes (Basel)
He L, Li L, Li Y, Sun Y, Zheng Z, Chu C, Chen S, Li L.   +7 more
europepmc   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights. [PDF]

Cell Rep Med
Wang Y, Olsen LK, Jiao F, Wang C, Jiang KX, Dou Y, Hu Y, Jiao L, Chen W, Elizarraras JM, Khare P, Yu N, Zhu H, Chen L, Lih TM, Eser PÖ, Martins Rodrigues F, Shi Z, Zhang C, Yu C, Heiman DI, Liao Y, Shafer PW, Choi S, Choi JM, Savage SR, Jaehnig EJ, Lei JT, Sun Y, Peng CW, Sun Z, Morenkov P, Zhang K, Geffen Y, Hess J, Kumar-Sinha C, Mani DR, Ding L, Getz G, Li QK, Omenn GS, Le A, Hostetter G, Newton CJ, Cai S, Ketchum KA, Robles AI, Mesri M, Minoo P, Camargo MC, An E, Hruban RH, Liu Z, Thiagarajan M, Dohlman AB, Jin RU, Huang L, Chan DW, Zhang H, Zhang B, Clinical Proteomic Tumor Analysis Consortium.   +60 more
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Anchor Relative Topology for Sparse Point Correspondence in Sensor-Derived Observations. [PDF]

Sensors (Basel)
Wang X, Shi L.
europepmc   +1 more source

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

Advanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo, Cheng‐Chen Hou, Wei Wang, Ya‐Xuan Zhu, Ling Li, Li‐Juan Liu, Chuan‐Jian Lu, Peng‐Fei Tu, Yang Liu, Rui‐Zhi Zhao, Ke‐Wu Zeng   +10 more
wiley   +1 more source

Accuracy Analysis of SINS/CNS Integrated Attitude Determination Based on Simplified Spatio-Temporal Model. [PDF]

Sensors (Basel)
Ruan C, Li H, Li C, Chen S, Hong Z.
europepmc   +1 more source