Results 231 to 240 of about 4,162,760 (300)

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

ELAVL1 overexpression potentiates cervical cancer malignancy via regulating the ACVRL1/CASP14 pathway. [PDF]

iScience
Liu J, Wang J, Gao Y, Cui X, Wang W, Ma H, Jiao Y, Xu J, Hao J, Xu Z, Li L, Hao M.   +11 more
europepmc   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Correction: SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice. [PDF]

Front Cell Infect Microbiol
de Oliveira SA, da Silva AAS, Hinton BT, Gomes GF, Cunha TM, Cerri PS, Sasso-Cerri E.   +6 more
europepmc   +1 more source

Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis

Advanced Science, EarlyView.
Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He, Ya Jin, Guosheng Liu, Hao Liu, Xinyi Zhu, Weipeng Xu, Wei Li, Meiyao He, Yao Shen, Bingxiao Li, Xuesong Yang, Xiaoyu Wang, Shasha Han   +12 more
wiley   +1 more source

Chlorogenic Acid Attenuates Busulfan-Induced Azoospermia in Rats: Antioxidant-Mediated Restoration of Spermatogenesis and Steroidogenesis - A Stereological and Molecular Analysis. [PDF]

JBRA Assist Reprod
Koohpeyma F, Karimi S.
europepmc   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy.

Cancer Cell
Mallard de La Varende AL, Tian AL, Thomas S, Lahmar I, Messaoudene M, Li S, Motiño O, Guillaume-Dit-Taunière H, Iebba V, Hurtado Y, Pham TN, Thélémaque C, Araujo-Voces M, Suissa D, Ly P, Reich E, Vitali G, Arlunno BT, Durand S, Aprahamian F, Leduc M, Forveille S, Kepp O, de la Calle-Fabregat C, Schippers A, Wagner N, Fournier PE, Honda K, Marmorino F, Cremolini C, Maleki Vareki S, Lenehan JG, Marabelle A, Danlos FX, Deligne M, Truntzer C, Ghiringhelli F, Ree AH, Bousquet PA, Meltzer S, Ginhoux F, Rummel D, Fu Y, Quinn RA, Alves Costa Silva C, Iacovelli R, Ciccarese C, Porcari S, Elkrief A, Routy B, Ianiro G, Derosa L, Kroemer G, Fidelle M, Zitvogel L.   +54 more
europepmc   +1 more source

MINISTAR to STARLITE: Evolution of a Miniaturized Prototype for Testing Attitude Sensors. [PDF]

Sensors (Basel)
Nardino V, Baccani C, Ceccherini M, Cecchi M, Focardi F, Franci E, Guzzi D, Manna F, Milli V, Pini J, Salvadori L, Raimondi V.   +11 more
europepmc   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source