Results 161 to 170 of about 391,398 (249)

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Protocol for investigating intracellular microbial diversity using single-cell RNA-seq in immune cells of SARS-CoV-2-positive and recovered patients. [PDF]

STAR Protoc
Soni J, Mehta P, Yadav S, Chattopadhyay P, Pandey R.   +4 more
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

A deep investigation of the poorly studied open cluster King 18 using CCD VRI, Gaia DR3 and 2MASS. [PDF]

Sci Rep
Ahmed NM, Bendary R, Samir RM, Elhosseiny EG.   +3 more
europepmc   +1 more source

A review of artificial intelligence in brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen, Richard L. J. Qiu, Tonghe Wang, Shadab Momin, Xiaofeng Yang   +4 more
wiley   +1 more source

Protocol for achieving enhanced snRNA-seq data quality using Quality Clustering. [PDF]

STAR Protoc
Tavi PJ, Ojanen J, Laitinen P, Linna-Kuosmanen S.   +3 more
europepmc   +1 more source

Position‐dependent offset corrections for ring applicator reconstruction in cervical cancer brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Due to the tight curvature in their design, ring applicators are usually associated with large positioning errors. The standard practice to correct for these deviations based on global offsets may not be sufficient to comply with the recommended tolerance.
Leon G. Aldrovandi, Matthias E. T. Dessein, Shelley M. Pearson, Shelley M. Bulling   +3 more
wiley   +1 more source

Fast analysis of Spatial Transcriptomics (FaST): an ultra lightweight and fast pipeline for the analysis of high resolution spatial transcriptomics. [PDF]

NAR Genom Bioinform
Fulci V.
europepmc   +1 more source

Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron, Remika Mito, Samuel F. Berkovic, Graeme D. Jackson   +3 more
wiley   +1 more source

Protocol to recover single-cell gene expression profiles from spatial transcriptomics data using cluster computing. [PDF]

STAR Protoc
Lee YJ, Chen H, Lugo-Martinez J.
europepmc   +1 more source