Results 181 to 190 of about 2,684,722 (398)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Testing Cluster Membership of Planetary Nebulae with High-precision Proper Motions. I. HST Observations of JaFu 1 Near the Globular Cluster Palomar 6

open access: yesThe Astronomical Journal
If a planetary nebula (PN) is shown to be a member of a star cluster, we obtain important new constraints on the mass and chemical composition of the PN’s progenitor star, which cannot be determined for PNe in the field.
Howard E. Bond   +2 more
doaj   +1 more source

NGC 2401: A template of the Norma-Cygnus Arm's young population in the Third Galactic Quadrant

open access: yes, 2005
Based on a deep optical CCD (UBV(RI)_C) photometric survey and on the Two-Micron All-Sky-Survey (2MASS) data we derived the main parameters of the open cluster NGC 2401. We found this cluster is placed at 6.3 $\pm$ 0.5 kpc (V_O - M_V = 14.0 \pm 0.2) from
A. Moitinho   +48 more
core   +3 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Star formation in clusters

open access: yes, 2006
HST is very well tailored for observations of extragalactic star clusters. One obvious reason is HST's high spatial resolution, but equally important is the wavelength range offered by the instruments on board HST, in particular the blue and near-UV coverage which is essential for age-dating young clusters.
openaire   +3 more sources

Properties of star-forming galaxies in a cluster and its surrounding structure at z=1.46

open access: yes, 2011
We conduct a narrow-band imaging survey of [OII] emitters over a 32'x23' area in and around the XMMXCS J2215.9-1738 cluster at z=1.46 with Subaru/Suprime-Cam, and select 380 [OII] emitting galaxies down to 1.4E-17 erg/s/cm2. Among them, 16 [OII] emitters
Asplund   +86 more
core   +1 more source

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