Results 201 to 210 of about 2,684,722 (398)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Kinematic substructure in star clusters constrains star cluster formation
Monthly Notices of the Royal Astronomical SocietyABSTRACT The spatial–kinematic structure of 48 young star clusters and associations is investigated. Moran’s I statistic is used to quantify the degree of kinematic substructure in each region, and the results are compared to those expected assuming the hierarchical or monolithic models of star cluster formation. Of the observed regions,
Becky Arnold, Nicholas J Wright
openaire +2 more sources
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
The Stellar Initial Mass Function of Early Dark Matter–free Gas Objects
The Astrophysical Journal LettersAmong the remarkable strides made by JWST is the discovery of the earliest star clusters found to date. These have been proposed as early progenitors of globular clusters, which are known to come from the early stages of star formation in the Universe ...
William Lake +8 more
doaj +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Measurements of neutral hydrogen in galactic star clusters [PDF]
, 1964 R. D. Davies, H. M. Tovmassian
openalex +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Open Star Clusters and Their Asymmetrical Tidal Tails
The Astrophysical JournalStars that evaporate from their star cluster by the energy equipartition process end up in either a leading or a trailing tidal tail. In Newtonian gravitation and for open star clusters in the solar vicinity, the tidal threshold, or práh, for escape is ...
Pavel Kroupa +6 more
doaj +1 more source