Results 51 to 60 of about 98,056 (310)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Cluster and Double Star observations of dipolarization [PDF]
We studied two types of dipolarization events with different IMF conditions when Cluster and Double Star (TC-1) were located in the same local time sector: 7 August 2004, 18:00-24:00 UT, during a disturbed southward/northward IMF interval, and 14
R. Nakamura +18 more
doaj +1 more source
As a novel technology, simultaneous transmitting and reflecting reconfigurable intelligent surface (STAR-RIS) provides users with full spatial coverage communication by modulating reflected and refracted signals.
Yi Peng +4 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The Chinese ground-based instrumentation in support of the combined Cluster/Double Star satellite measurements [PDF]
Ground-based observations can be used to provide substantial support for Cluster/Double Star measurements and greatly enhance the mission's scientific return. There are six Chinese ground stations involved in coordinated cluster/Double Star and ground-
R.-Y. Liu +12 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Starburst galaxies in the Hydra I cluster
Studying the impact of environment on star formation and quenching pathways requires statistically relevant samples of galaxies in a wide mass range. We present a new catalog of 196 galaxies of the nearby Hydra I cluster out to ∼1.75r200, consisting of ...
de la Casa Clara C. +12 more
doaj +1 more source

