Results 171 to 180 of about 2,681,556 (391)
Star cluster evolution, dynamical age estimation and the kinematical signature of star formation [PDF]
, 1995 Pavel Kroupa
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Is Earendel a Star Cluster?: Metal-poor Globular Cluster Progenitors at z ∼ 6
The Astrophysical Journal LettersThe strongly lensed z ∼ 6 Sunrise galaxy offers an incredible opportunity to investigate star formation in the early Universe on parsec or smaller scales.
Massimo Pascale +3 more
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Stellar populations and star cluster formation in interacting galaxies with the Advanced Camera for Surveys*1 [PDF]
, 2003 Richard de Grijs
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Astrophysical JournalStars in an open cluster are assumed to have formed from a broadly homogeneous distribution of gas, implying that they should be chemically homogeneous.
Amaya Sinha +6 more
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STAR-FORMING GALAXIES IN THE HERCULES CLUSTER: Hα IMAGING OF A2151 [PDF]
, 2009 Bernabé Cedrés +11 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Disk-locking Regulates Stellar Rotation in Young Clusters: Insights from NGC 2264
The Astrophysical JournalMany young clusters possess extended main sequences, a phenomenon commonly ascribed to stellar rotation. However, the mechanism behind their very wide stellar rotation distributions remains unclear.
Yutian Bu +3 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source