Results 41 to 50 of about 71,766 (252)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

PHANGS–JWST First Results: Dust-embedded Star Clusters in NGC 7496 Selected via 3.3 μm PAH Emission

The Astrophysical Journal Letters, 2023
The earliest stages of star formation occur enshrouded in dust and are not observable in the optical. Here we leverage the extraordinary new high-resolution infrared imaging from JWST to begin the study of dust-embedded star clusters in nearby galaxies ...
M. Jimena Rodríguez, Janice C. Lee, B. C. Whitmore, David A. Thilker, Daniel Maschmann, Rupali Chandar, Sinan Deger, Médéric Boquien, Daniel A. Dale, Kirsten L. Larson, Thomas G. Williams, Hwihyun Kim, Eva Schinnerer, Erik Rosolowsky, Adam K. Leroy, Eric Emsellem, Karin M. Sandstrom, J. M. Diederik Kruijssen, Kathryn Grasha, Elizabeth J. Watkins, Ashley. T. Barnes, Mattia C. Sormani, Jaeyeon Kim, Gagandeep S. Anand, Mélanie Chevance, F. Bigiel, Ralf S. Klessen, Hamid Hassani, Daizhong Liu, Christopher M. Faesi, Yixian Cao, Francesco Belfiore, Ismael Pessa, Kathryn Kreckel, Brent Groves, Jérôme Pety, Rémy Indebetouw, Oleg V. Egorov, Guillermo A. Blanc, Toshiki Saito, Annie Hughes   +40 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Emergence of a Lithium Dip in ∼35 Myr “Snake” Open Clusters

The Astrophysical Journal Letters
We report the discovery of a lithium dip (Li dip) in the stellar “Snake” (age = 35 ± 5 Myr), challenging the classical view that Li dips emerge only at ages ≳150 Myr.
Yun-Yi Zhang, Hai-Jun Tian, Jian-Rong Shi, Cheng-Cheng Xie, Xiang-Ming Yang   +4 more
doaj   +1 more source

Identifying 46 New Open Cluster Candidates in Gaia EDR3 Using a Hybrid pyUPMASK and Random Forest Method

The Astrophysical Journal Supplement Series, 2023
Open clusters (OCs) are regarded as tracers to understand stellar evolution theory and validate stellar models. In this study, we presented a robust approach to identifying OCs.
Huanbin Chi, Shoulin Wei, Feng Wang, Zhongmu Li   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

oMEGACat. III. Multiband Photometry and Metallicities Reveal Spatially Well-mixed Populations within ω Centauri’s Half-light Radius

The Astrophysical Journal
ω Centauri, the most massive globular cluster in the Milky Way, has long been suspected to be the stripped nucleus of a dwarf galaxy that fell into the Galaxy a long time ago.
M. S. Nitschai, N. Neumayer, M. Häberle, C. Clontz, A. C. Seth, A. P. Milone, M. Alfaro-Cuello, A. Bellini, S. Dreizler, A. Feldmeier-Krause, T.-O. Husser, N. Kacharov, S. Kamann, M. Latour, M. Libralato, G. van de Ven, K. Voggel, Z. Wang   +17 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Velocity Dispersion Profile of Nine Open Clusters in the Solar Neighborhood

The Astrophysical Journal
We analyze the velocity dispersion profiles of nine open clusters in the solar neighborhood using kinematic data from Gaia DR 3, aiming to identify potential dynamical signatures of stellar-mass black holes through a comparison of theoretical and ...
Bingqian Ma, Xiaoying Pang, Sambaran Banerjee, Pengfei Ren, M. B. N. Kouwenhoven   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source