Results 31 to 40 of about 75,652 (263)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The Astronomical JournalTrumpler 5 is a populous, intermediate-age (∼3 Gyr), metal-poor ([Fe/H] ∼ −0.4) open cluster, located at a distance of approximately ∼3050 pc. This is a well-studied cluster for its broadened main-sequence (MS) and blue straggler star (BSS) population ...
Komal Chand, Anju Panthi, Kaushar Vaidya
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Astrophysical JournalMost of the dynamical mass loss from star clusters is thought to be caused by the time variability of the tidal field (“tidal shocks”). Systematic studies of tidal shocks have been hampered by the fact that each tidal history is unique, implying both a ...
Jeremy J. Webb +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Open Cluster Study Using Gaia. I. Membership and Cluster Properties
The Astrophysical JournalStar clusters are interesting laboratories to study star formation, single and binary stellar evolution, and stellar dynamics. We have used the exquisite data from Gaia’s Data Release 3 (DR3) to study 21 relatively rich and nearby open clusters with ...
Anindya Ganguly +2 more
doaj +1 more source
The Astrophysical Journal, 2023 We present a photometric analysis of globular cluster 47 Tuc (NGC 104) using near-IR imaging data from the GeMS/GSAOI Galactic Globular Cluster Survey (G4CS), which is in operation at Gemini-South telescope.
Mirko Simunovic +7 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
An In-depth Investigation of the Primordial Cluster Pair ASCC 19 and ASCC 21
The Astronomical JournalUtilizing Gaia data from the literature, we report a new young (∼8.9 Myr) cluster pair, ASCC 19 and ASCC 21, located near the Orion star-forming complex. The clusters are separated by a 3D distance of 27.00 ± 7.51 pc.
Qingshun Hu +6 more
doaj +1 more source