Results 221 to 230 of about 993,735 (252)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Models and observational predictions of dust traps in protoplanetary discs. [PDF]

Astrophys Space Sci
Pinilla P.
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Cavitation-enhanced aroma and browning: A multiscale study of star anise (Illicium verum Hook. f.) pretreated by ultrasound and electrolyzed water. [PDF]

Ultrason Sonochem
Zhang S, Huang Q, Kuang X, Guo C, Jiang Y, Zhang F, Pan D, Du M, Devahastin S, Yi J.   +9 more
europepmc   +1 more source

A large, long-lived, slowly-expanding superbubble across the Perseus arm. [PDF]

Nat Commun
Chen B, Li G, Yuan H, Xiang M, Zhou J, Chen P, Krause M, Coombs A.   +7 more
europepmc   +1 more source

High Deuteration of Methanol in L1544. [PDF]

ACS Earth Space Chem
Spezzano S, Riedel W, Caselli P, Sipilä O, Lin Y, Bunn HA, Redaelli E, Coudert LH, Megías A, Jimenez-Serra I.   +9 more
europepmc   +1 more source

Annealing and passivation study of germanium on silicon (GOS) mid-infrared waveguide for sensing applications. [PDF]

Sci Rep
Ang RCF, Goh JS, Tobing LYM, Lim LW, Tong ASK, Fong AWK, Chen Z, Ng DKT.   +7 more
europepmc   +1 more source

STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism. [PDF]

Stem Cell Reports
Tan WX, Amirruddin NS, Lim EXH, Hu M, Muralidharan S, Benke PI, Torta F, Hoon S, Soetedjo AAP, Lau HH, Ng NHJ, Rutter GA, Teo AKK.   +12 more
europepmc   +1 more source

Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes. [PDF]

Genome Biol
Lee H, Cao X, Parada GE, Li JD, Iosub IA, Braunschweig U, Rebelo K, Ule J, Wan Y, Blencowe BJ.   +9 more
europepmc   +1 more source