Results 201 to 210 of about 1,022,915 (352)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

In-situ Star Formation in the Outskirts of the Large Magellanic Cloud: <i>Gaia</i> DR2 Confirmation. [PDF]

Astrophys J, 2018
Casetti-Dinescu DI, Girard TM, Bidin CM, Zhang L, Mendez RA, Vieira K, Korchagin VI, van Altena WF.   +7 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Star formation shut down by multiphase gas outflow in a galaxy at a redshift of 2.45. [PDF]

Nature
Belli S, Park M, Davies RL, Mendel JT, Johnson BD, Conroy C, Benton C, Bugiani L, Emami R, Leja J, Li Y, Maheson G, Mathews EP, Naidu RP, Nelson EJ, Tacchella S, Terrazas BA, Weinberger R.   +17 more
europepmc   +1 more source

Astrochemical evolution along star formation: Overview of the IRAM Large Program ASAI. [PDF]

Mon Not R Astron Soc, 2018
Lefloch B, Bachiller R, Ceccarelli C, Cernicharo J, Codella C, Fuente A, Kahane C, López-Sepulcre A, Tafalla M, Vastel C, Caux E, González-García M, Bianchi E, Gómez-Ruiz A, Holdship J, Mendoza E, Ospina-Zamudio J, Podio L, Quénard D, Roueff E, Sakai N, Viti S, Yamamoto S, Yoshida K, Favre C, Monfredini T, Quitián-Lara HM, Marcelino N, Boechat-Roberty HM, Cabrit S.   +29 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Little Engines That Could? Globular clusters contribute significantly to reionization-era star formation. [PDF]

Mon Not R Astron Soc, 2018
Boylan-Kolchin M.
europepmc   +1 more source

New insights into the interstellar medium of the dwarf galaxy IC 10: connection between magnetic fields, the radio–infrared correlation and star formation [PDF]

, 2017
Aritra Basu, Sambit Roychowdhury, V. Heesen, Rainer Beck, E. Brinks, Jonathan Westcott, L. Hindson   +6 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From the top down and back up again: star cluster structure from hierarchical star formation. [PDF]

Mon Not R Astron Soc, 2018
Grudić MY, Guszejnov D, Hopkins PF, Lamberts A, Boylan-Kolchin M, Murray N, Schmitz D.   +6 more
europepmc   +1 more source