Results 41 to 50 of about 194,114 (263)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

The star-formation history of the universe [PDF]

open access: yesAstrophysics and Space Science, 1999
10 pages, 7 figures, to appear in proceedings of the Ringberg Workshop on 'Ultraluminous galaxies: Monsters or Babies ?', 1999, eds D.Lutz and L.Tacconi, Astrophys.Space Sci., in ...
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

How leaky? A large parameter study of leaky dust traps to quantify the transport of pebbles and ice in protoplanetary discs

open access: yesAstronomy & Astrophysics
In protoplanetary discs, the presence of dust traps can significantly alter the transport of solids from the outer to the inner regions, and hence they are often invoked as an explanation for the chemical diversity of inner discs observed with the James ...
Houge Adrien   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Exploring the conditions for forming planetesimals via the streaming instability and planetary systems via pebble accretion

open access: yesAstronomy & Astrophysics
The streaming instability and pebble accretion are two physical mechanisms with demonstrated potentials to drive, respectively, the formation of planetesimals and the growth of planetary systems containing a diverse range of planetary types.
Johansen Anders, Lyra Wladimir
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

A giant solution to the disk mass budget problem of planet formation

open access: yesFrontiers in Astronomy and Space Sciences
Understanding how dust evolves in protoplanetary disks is crucial to constraining the initial conditions of planet formation. The apparent “mass budget problem”, which stems from the comparison of the observed disk masses to the ones inferred for ...
Sofia Savvidou, Sofia Savvidou
doaj   +1 more source

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