Results 171 to 180 of about 563,924 (339)

Young Stellar Objects in the Massive Star-forming Regions W51 and W43. [PDF]

open access: yesAstrophys J, 2017
Saral G   +8 more
europepmc   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Star Formation in the Lopsided Galaxy Arp 291

open access: yesThe Astrophysical Journal
We have investigated the star formation process taking place in the lopsided galaxy Arp 291, based on narrowband images in the H α , [N ii ] λ 6583, and [O iii ] λ 5007 emission lines, obtained using the modern tunable photometer MaNGaL at the Caucasus ...
Irina S. Proshina, Dmitriy V. Oparin
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

open access: yesMolecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen   +5 more
wiley   +1 more source

Fitting Methods for Probability Distribution Functions in Turbulent Star-forming Clouds

open access: yesThe Astrophysical Journal
We use a suite of 3D simulations of star-forming molecular clouds, with and without stellar feedback and magnetic fields, to investigate the effectiveness of different fitting methods for volume and column density probability distribution functions (PDFs)
Avery Kiihne   +4 more
doaj   +1 more source

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